Identifying risk factors for refractory febrile neutropenia in patients with lung cancer

Masaki Fujita, Shoji Tokunaga, Satoshi Ikegame, Eiji Harada, Takemasa Matsumoto, Junji Uchino, Kentaro Watanabe, Yoichi Nakanishi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Information about the development of febrile neutropenia in patients with solid tumors remains insufficient. In this study, we tried to identify the risk factors for refractory febrile neutropenia in patients with lung cancer. A total of 59 neutropenic fever episodes associated with anti-tumor chemotherapy for lung cancer were retrospectively analyzed. We compared patient characteristics according to their initial response to treatment with antibiotics. For 34 of 59 (58%) episodes a response to initial antibiotics was obtained whereas 25 of 59 (42%) were refractory to treatment. Multivariate analysis demonstrated independent risk factors for refractory febrile neutropenia with lung cancer. These risk factors were the severity of febrile neutropenia (odds ratio (OR) 6.11; 95% confidence interval (CI) 1.85-20.14) and C-reactive protein more than 10 mg/dl (OR 4.39; 95% CI 1.22-15.74). These factors could predict outcome for patients with lung cancer who develop refractory febrile neutropenia.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalJournal of Infection and Chemotherapy
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2012

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Fujita, M., Tokunaga, S., Ikegame, S., Harada, E., Matsumoto, T., Uchino, J., Watanabe, K., & Nakanishi, Y. (2012). Identifying risk factors for refractory febrile neutropenia in patients with lung cancer. Journal of Infection and Chemotherapy, 18(1), 53-58. https://doi.org/10.1007/s10156-011-0283-5