Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?

Masaru Harada, Yuichi Honma, Tomoharu Yoshizumi, Keiichiro Kumamoto, Shinji Oe, Noboru Harada, Aya Tanimoto, Kei Yabuki, Tsukasa Karasuyama, Akitoshi Yoneda, Michihiko Shibata

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalMedical Molecular Morphology
Issue number1
Publication statusPublished - Mar 1 2020

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology


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