Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?

Masaru Harada; Yuichi Honma; Tomoharu Yoshizumi; Keiichiro Kumamoto; Shinji Oe; Noboru Harada; Aya Tanimoto; Kei Yabuki; Tsukasa Karasuyama; Akitoshi Yoneda; Michihiko Shibata

doi:10.1007/s00795-019-00227-4

Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?

Masaru Harada, Yuichi Honma, Tomoharu Yoshizumi, Keiichiro Kumamoto, Shinji Oe, Noboru Harada, Aya Tanimoto, Kei Yabuki, Tsukasa Karasuyama, Akitoshi Yoneda, Michihiko Shibata

Liver Surgery

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.

Original language	English
Pages (from-to)	50-55
Number of pages	6
Journal	Medical Molecular Morphology
Volume	53
Issue number	1
DOIs	https://doi.org/10.1007/s00795-019-00227-4
Publication status	Published - Mar 1 2020

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Molecular Biology

Access to Document

10.1007/s00795-019-00227-4

Fingerprint Dive into the research topics of 'Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?'. Together they form a unique fingerprint.

Cite this

Idiopathic copper toxicosis : is abnormal copper metabolism a primary cause of this disease? / Harada, Masaru; Honma, Yuichi; Yoshizumi, Tomoharu; Kumamoto, Keiichiro; Oe, Shinji; Harada, Noboru; Tanimoto, Aya; Yabuki, Kei; Karasuyama, Tsukasa; Yoneda, Akitoshi; Shibata, Michihiko.

In: Medical Molecular Morphology, Vol. 53, No. 1, 01.03.2020, p. 50-55.

Research output: Contribution to journal › Article › peer-review

@article{39e8b4cdf13a44d28b3432c2449797c5,

title = "Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?",

abstract = "Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.",

author = "Masaru Harada and Yuichi Honma and Tomoharu Yoshizumi and Keiichiro Kumamoto and Shinji Oe and Noboru Harada and Aya Tanimoto and Kei Yabuki and Tsukasa Karasuyama and Akitoshi Yoneda and Michihiko Shibata",

note = "Funding Information: Acknowledgements This work was supported in part by JSPS KAK-ENHI Grant No. 18K07988 to MH.",

year = "2020",

month = mar,

day = "1",

doi = "10.1007/s00795-019-00227-4",

language = "English",

volume = "53",

pages = "50--55",

journal = "Medical Molecular Morphology",

issn = "1860-1480",

number = "1",

}

TY - JOUR

T1 - Idiopathic copper toxicosis

T2 - is abnormal copper metabolism a primary cause of this disease?

AU - Harada, Masaru

AU - Honma, Yuichi

AU - Yoshizumi, Tomoharu

AU - Kumamoto, Keiichiro

AU - Oe, Shinji

AU - Harada, Noboru

AU - Tanimoto, Aya

AU - Yabuki, Kei

AU - Karasuyama, Tsukasa

AU - Yoneda, Akitoshi

AU - Shibata, Michihiko

N1 - Funding Information: Acknowledgements This work was supported in part by JSPS KAK-ENHI Grant No. 18K07988 to MH.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.

AB - Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.

UR - http://www.scopus.com/inward/record.url?scp=85067048697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067048697&partnerID=8YFLogxK

U2 - 10.1007/s00795-019-00227-4

DO - 10.1007/s00795-019-00227-4

M3 - Article

C2 - 31161407

AN - SCOPUS:85067048697

VL - 53

SP - 50

EP - 55

JO - Medical Molecular Morphology

JF - Medical Molecular Morphology

SN - 1860-1480

IS - 1

ER -