TY - JOUR
T1 - Idiopathic copper toxicosis
T2 - is abnormal copper metabolism a primary cause of this disease?
AU - Harada, Masaru
AU - Honma, Yuichi
AU - Yoshizumi, Tomoharu
AU - Kumamoto, Keiichiro
AU - Oe, Shinji
AU - Harada, Noboru
AU - Tanimoto, Aya
AU - Yabuki, Kei
AU - Karasuyama, Tsukasa
AU - Yoneda, Akitoshi
AU - Shibata, Michihiko
N1 - Funding Information:
Acknowledgements This work was supported in part by JSPS KAK-ENHI Grant No. 18K07988 to MH.
Publisher Copyright:
© 2019, The Japanese Society for Clinical Molecular Morphology.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.
AB - Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.
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U2 - 10.1007/s00795-019-00227-4
DO - 10.1007/s00795-019-00227-4
M3 - Article
C2 - 31161407
AN - SCOPUS:85067048697
VL - 53
SP - 50
EP - 55
JO - Medical Molecular Morphology
JF - Medical Molecular Morphology
SN - 1860-1480
IS - 1
ER -