Idiopathic disseminated bacillus Calmette-Guerin infection in three infants

Jun Kido, Tomoyuki Mizukami, Osamu Ohara, Hidetoshi Takada, Masaaki Yanai

Research output: Contribution to journalArticle

Abstract

We describe the cases of three infants between 4 and 9 months of age with disseminated bacillus Calmette-Guerin (BCG) infection who developed persistent fever, skin rash, and multiple chest nodules visible on computed tomography 22-34 days after BCG vaccination. These infants were healthy before inoculation, and their detailed immunological profiles, including T cell and neutrophil levels, were within normal range. Most reported BCG cases involve impaired immunity, such as children with chronic granulomatous disease, severe combined immunodeficiency, or human immunodeficiency virus infections. Because of their immature immune systems, BCG vaccination can be hazardous even in early infants without immune abnormalities. Hence, we advise caution when administering BCG vaccines to early infants.

Original languageEnglish
Pages (from-to)750-753
Number of pages4
JournalPediatrics International
Volume57
Issue number4
DOIs
Publication statusPublished - Aug 1 2015

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Mycobacterium bovis
Infection
Vaccination
BCG Vaccine
Chronic Granulomatous Disease
Severe Combined Immunodeficiency
Virus Diseases
Exanthema
Immune System
Immunity
Reference Values
Neutrophils
Fever
Thorax
Tomography
HIV
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Idiopathic disseminated bacillus Calmette-Guerin infection in three infants. / Kido, Jun; Mizukami, Tomoyuki; Ohara, Osamu; Takada, Hidetoshi; Yanai, Masaaki.

In: Pediatrics International, Vol. 57, No. 4, 01.08.2015, p. 750-753.

Research output: Contribution to journalArticle

Kido, J, Mizukami, T, Ohara, O, Takada, H & Yanai, M 2015, 'Idiopathic disseminated bacillus Calmette-Guerin infection in three infants', Pediatrics International, vol. 57, no. 4, pp. 750-753. https://doi.org/10.1111/ped.12623
Kido, Jun ; Mizukami, Tomoyuki ; Ohara, Osamu ; Takada, Hidetoshi ; Yanai, Masaaki. / Idiopathic disseminated bacillus Calmette-Guerin infection in three infants. In: Pediatrics International. 2015 ; Vol. 57, No. 4. pp. 750-753.
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