IgA level is associated with risk for mortality in an eighty-year-old population

Takehiro Torisu, Yutaka Takata, Toshihiro Ansai, Inho Soh, Shuji Awano, Kazuo Sonoki, Shuntaro Kagiyama, Ikuo Nakamichi, Akihiro Yoshida, Tomoko Hamasaki, Takayuki Matsumoto, Mitsuo Iida, Tadamichi Takehara

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5 Citations (Scopus)

Abstract

Background: Immunoglobulin levels are elevated in the older people. However, it is unknown whether these levels are related to mortality. Object: To evaluate the association between immunoglobulin levels and mortality. Methods: The study population included 697 individuals (277 males and 420 females) of 1,282 eighty-year-old individuals residing in the Fukuoka prefecture, Japan. The participants were followed for 4 years after the baseline examination. Results: The hyper-IgA group, defined as a serum IgA level >400 mg/dl, had high mortality using Kaplan-Meier analysis (log rank, p = 0.037). Multivariate Cox regression analyses revealed a high risk of mortality (hazard rate = 1.233, 95% confidence interval 1.109-1.491, p = 0.031) after adjusting for covariates. The high risk of mortality in the hyper-IgA group was significant in males, but not in females. Moreover, Kaplan-Meier analysis revealed that IgA was related to cancer mortality in males (log rank, p = 0.031), but not to pneumonia or cardiovascular disease. IgM and IgG levels were not related to high risk of mortality. Conclusion: Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalGerontology
Volume55
Issue number2
DOIs
Publication statusPublished - Mar 1 2009

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

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    Torisu, T., Takata, Y., Ansai, T., Soh, I., Awano, S., Sonoki, K., Kagiyama, S., Nakamichi, I., Yoshida, A., Hamasaki, T., Matsumoto, T., Iida, M., & Takehara, T. (2009). IgA level is associated with risk for mortality in an eighty-year-old population. Gerontology, 55(2), 179-185. https://doi.org/10.1159/000162260