IgA level is associated with risk for mortality in an eighty-year-old population

takehiro torisu, Yutaka Takata, Toshihiro Ansai, Inho Soh, Shuji Awano, Kazuo Sonoki, Shuntaro Kagiyama, Ikuo Nakamichi, Akihiro Yoshida, Tomoko Hamasaki, Takayuki Matsumoto, Mitsuo Iida, Tadamichi Takehara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Immunoglobulin levels are elevated in the older people. However, it is unknown whether these levels are related to mortality. Object: To evaluate the association between immunoglobulin levels and mortality. Methods: The study population included 697 individuals (277 males and 420 females) of 1,282 eighty-year-old individuals residing in the Fukuoka prefecture, Japan. The participants were followed for 4 years after the baseline examination. Results: The hyper-IgA group, defined as a serum IgA level >400 mg/dl, had high mortality using Kaplan-Meier analysis (log rank, p = 0.037). Multivariate Cox regression analyses revealed a high risk of mortality (hazard rate = 1.233, 95% confidence interval 1.109-1.491, p = 0.031) after adjusting for covariates. The high risk of mortality in the hyper-IgA group was significant in males, but not in females. Moreover, Kaplan-Meier analysis revealed that IgA was related to cancer mortality in males (log rank, p = 0.031), but not to pneumonia or cardiovascular disease. IgM and IgG levels were not related to high risk of mortality. Conclusion: Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalGerontology
Volume55
Issue number2
DOIs
Publication statusPublished - Mar 1 2009

Fingerprint

Immunoglobulin A
Mortality
Population
Kaplan-Meier Estimate
Immunoglobulins
Serum
Immunoglobulin M
Neoplasms
Pneumonia
Japan
Cardiovascular Diseases
Immunoglobulin G
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

Cite this

torisu, T., Takata, Y., Ansai, T., Soh, I., Awano, S., Sonoki, K., ... Takehara, T. (2009). IgA level is associated with risk for mortality in an eighty-year-old population. Gerontology, 55(2), 179-185. https://doi.org/10.1159/000162260

IgA level is associated with risk for mortality in an eighty-year-old population. / torisu, takehiro; Takata, Yutaka; Ansai, Toshihiro; Soh, Inho; Awano, Shuji; Sonoki, Kazuo; Kagiyama, Shuntaro; Nakamichi, Ikuo; Yoshida, Akihiro; Hamasaki, Tomoko; Matsumoto, Takayuki; Iida, Mitsuo; Takehara, Tadamichi.

In: Gerontology, Vol. 55, No. 2, 01.03.2009, p. 179-185.

Research output: Contribution to journalArticle

torisu, T, Takata, Y, Ansai, T, Soh, I, Awano, S, Sonoki, K, Kagiyama, S, Nakamichi, I, Yoshida, A, Hamasaki, T, Matsumoto, T, Iida, M & Takehara, T 2009, 'IgA level is associated with risk for mortality in an eighty-year-old population', Gerontology, vol. 55, no. 2, pp. 179-185. https://doi.org/10.1159/000162260
torisu, takehiro ; Takata, Yutaka ; Ansai, Toshihiro ; Soh, Inho ; Awano, Shuji ; Sonoki, Kazuo ; Kagiyama, Shuntaro ; Nakamichi, Ikuo ; Yoshida, Akihiro ; Hamasaki, Tomoko ; Matsumoto, Takayuki ; Iida, Mitsuo ; Takehara, Tadamichi. / IgA level is associated with risk for mortality in an eighty-year-old population. In: Gerontology. 2009 ; Vol. 55, No. 2. pp. 179-185.
@article{0e562746d06b4de984459a12ef465fe7,
title = "IgA level is associated with risk for mortality in an eighty-year-old population",
abstract = "Background: Immunoglobulin levels are elevated in the older people. However, it is unknown whether these levels are related to mortality. Object: To evaluate the association between immunoglobulin levels and mortality. Methods: The study population included 697 individuals (277 males and 420 females) of 1,282 eighty-year-old individuals residing in the Fukuoka prefecture, Japan. The participants were followed for 4 years after the baseline examination. Results: The hyper-IgA group, defined as a serum IgA level >400 mg/dl, had high mortality using Kaplan-Meier analysis (log rank, p = 0.037). Multivariate Cox regression analyses revealed a high risk of mortality (hazard rate = 1.233, 95{\%} confidence interval 1.109-1.491, p = 0.031) after adjusting for covariates. The high risk of mortality in the hyper-IgA group was significant in males, but not in females. Moreover, Kaplan-Meier analysis revealed that IgA was related to cancer mortality in males (log rank, p = 0.031), but not to pneumonia or cardiovascular disease. IgM and IgG levels were not related to high risk of mortality. Conclusion: Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.",
author = "takehiro torisu and Yutaka Takata and Toshihiro Ansai and Inho Soh and Shuji Awano and Kazuo Sonoki and Shuntaro Kagiyama and Ikuo Nakamichi and Akihiro Yoshida and Tomoko Hamasaki and Takayuki Matsumoto and Mitsuo Iida and Tadamichi Takehara",
year = "2009",
month = "3",
day = "1",
doi = "10.1159/000162260",
language = "English",
volume = "55",
pages = "179--185",
journal = "Gerontology",
issn = "0304-324X",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - IgA level is associated with risk for mortality in an eighty-year-old population

AU - torisu, takehiro

AU - Takata, Yutaka

AU - Ansai, Toshihiro

AU - Soh, Inho

AU - Awano, Shuji

AU - Sonoki, Kazuo

AU - Kagiyama, Shuntaro

AU - Nakamichi, Ikuo

AU - Yoshida, Akihiro

AU - Hamasaki, Tomoko

AU - Matsumoto, Takayuki

AU - Iida, Mitsuo

AU - Takehara, Tadamichi

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Background: Immunoglobulin levels are elevated in the older people. However, it is unknown whether these levels are related to mortality. Object: To evaluate the association between immunoglobulin levels and mortality. Methods: The study population included 697 individuals (277 males and 420 females) of 1,282 eighty-year-old individuals residing in the Fukuoka prefecture, Japan. The participants were followed for 4 years after the baseline examination. Results: The hyper-IgA group, defined as a serum IgA level >400 mg/dl, had high mortality using Kaplan-Meier analysis (log rank, p = 0.037). Multivariate Cox regression analyses revealed a high risk of mortality (hazard rate = 1.233, 95% confidence interval 1.109-1.491, p = 0.031) after adjusting for covariates. The high risk of mortality in the hyper-IgA group was significant in males, but not in females. Moreover, Kaplan-Meier analysis revealed that IgA was related to cancer mortality in males (log rank, p = 0.031), but not to pneumonia or cardiovascular disease. IgM and IgG levels were not related to high risk of mortality. Conclusion: Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.

AB - Background: Immunoglobulin levels are elevated in the older people. However, it is unknown whether these levels are related to mortality. Object: To evaluate the association between immunoglobulin levels and mortality. Methods: The study population included 697 individuals (277 males and 420 females) of 1,282 eighty-year-old individuals residing in the Fukuoka prefecture, Japan. The participants were followed for 4 years after the baseline examination. Results: The hyper-IgA group, defined as a serum IgA level >400 mg/dl, had high mortality using Kaplan-Meier analysis (log rank, p = 0.037). Multivariate Cox regression analyses revealed a high risk of mortality (hazard rate = 1.233, 95% confidence interval 1.109-1.491, p = 0.031) after adjusting for covariates. The high risk of mortality in the hyper-IgA group was significant in males, but not in females. Moreover, Kaplan-Meier analysis revealed that IgA was related to cancer mortality in males (log rank, p = 0.031), but not to pneumonia or cardiovascular disease. IgM and IgG levels were not related to high risk of mortality. Conclusion: Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.

UR - http://www.scopus.com/inward/record.url?scp=62249144240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62249144240&partnerID=8YFLogxK

U2 - 10.1159/000162260

DO - 10.1159/000162260

M3 - Article

C2 - 18836254

AN - SCOPUS:62249144240

VL - 55

SP - 179

EP - 185

JO - Gerontology

JF - Gerontology

SN - 0304-324X

IS - 2

ER -