IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury

T. Arai, K. Hiromatsu, N. Kobayashi, M. Takano, H. Ishida, Y. Nimura, Y. Yoshikai

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The effects of exogenous cAMP, dibutyryl cAMP (DBcAMP) on LPS-induced liver injury were examined in mice made hypersensitive to LPS by treatment with i.v. injection of Propionibacterium acnes. In vivo administration of DBcAMP significantly protected P. acnes-treated mice from LPS-induced liver injury, including apoptosis of hepatocytes. DBcAMP significantly increased circulating IL-10 level in correlation with suppression of the TNF-α level after LPS challenge in P. acnes-treated mice. Treatment with anti-IL-10 mAb abrogated the protective effect of DBcAMP on LPS-induced liver injury. Similar to in vivo findings, addition of DBcAMP to in vitro culture of liver adherent cells from P. acnes-treated mice enhanced IL-10 synthesis after LPS stimulation. These results suggest that the increment in IL-10 production by liver adherent cells is involved in the protective effect of DBcAMP on LPS- induced inflammatory liver injury.

Original languageEnglish
Pages (from-to)5743-5749
Number of pages7
JournalJournal of Immunology
Volume155
Issue number12
Publication statusPublished - 1995
Externally publishedYes

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Endotoxins
Cyclic AMP
Interleukin-10
Propionibacterium acnes
Liver
Wounds and Injuries
Hepatocytes
Apoptosis
Injections
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Arai, T., Hiromatsu, K., Kobayashi, N., Takano, M., Ishida, H., Nimura, Y., & Yoshikai, Y. (1995). IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. Journal of Immunology, 155(12), 5743-5749.

IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. / Arai, T.; Hiromatsu, K.; Kobayashi, N.; Takano, M.; Ishida, H.; Nimura, Y.; Yoshikai, Y.

In: Journal of Immunology, Vol. 155, No. 12, 1995, p. 5743-5749.

Research output: Contribution to journalArticle

Arai, T, Hiromatsu, K, Kobayashi, N, Takano, M, Ishida, H, Nimura, Y & Yoshikai, Y 1995, 'IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury', Journal of Immunology, vol. 155, no. 12, pp. 5743-5749.
Arai, T. ; Hiromatsu, K. ; Kobayashi, N. ; Takano, M. ; Ishida, H. ; Nimura, Y. ; Yoshikai, Y. / IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. In: Journal of Immunology. 1995 ; Vol. 155, No. 12. pp. 5743-5749.
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AU - Ishida, H.

AU - Nimura, Y.

AU - Yoshikai, Y.

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