IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury

T. Arai, K. Hiromatsu, N. Kobayashi, M. Takano, H. Ishida, Y. Nimura, Y. Yoshikai

    Research output: Contribution to journalArticlepeer-review

    96 Citations (Scopus)

    Abstract

    The effects of exogenous cAMP, dibutyryl cAMP (DBcAMP) on LPS-induced liver injury were examined in mice made hypersensitive to LPS by treatment with i.v. injection of Propionibacterium acnes. In vivo administration of DBcAMP significantly protected P. acnes-treated mice from LPS-induced liver injury, including apoptosis of hepatocytes. DBcAMP significantly increased circulating IL-10 level in correlation with suppression of the TNF-α level after LPS challenge in P. acnes-treated mice. Treatment with anti-IL-10 mAb abrogated the protective effect of DBcAMP on LPS-induced liver injury. Similar to in vivo findings, addition of DBcAMP to in vitro culture of liver adherent cells from P. acnes-treated mice enhanced IL-10 synthesis after LPS stimulation. These results suggest that the increment in IL-10 production by liver adherent cells is involved in the protective effect of DBcAMP on LPS- induced inflammatory liver injury.

    Original languageEnglish
    Pages (from-to)5743-5749
    Number of pages7
    JournalJournal of Immunology
    Volume155
    Issue number12
    Publication statusPublished - 1995

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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