IL-15 is elevated in the patients of postoperative enterocolitis

Toshihiko Mayumi, Jun Takezawa, Hideo Takahashi, Haruo Yamaguchi, Hitoshi Nishimura, Atsushi Enomoto, Satoshi Ichiyama, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Serum interleukin 15 (IL-15) levels were measured in 77 patients who were consecutively admitted to our intensive care unit. Postoperative enterocolitis occurred in four patients and Methicillin-resistant Staphylococcus aureus (MRSA), but not Clostridium defficile, was identified in the faecal specimens from these patients. The IL-15 levels in the patients with MRSA enterocolitis were significantly elevated compared with those of other MRSA infections without enterocolitis including pneumonia (n = 6) and cholangitis (n = 1), and other MRSA non-colonized patients (n = 66) (21.2 ± 5.2 pg/ml vs 4.3 ± 0.2, 4.3 ± 0.5). Notably, an increase in serum IL-15 was observed just before clinical manifestation of severe diarrhoea. Our findings suggest that IL-15 may be associated in the pathogenesis of postoperative enterocolitis and its serum level may be a severity indicator of the disease.

    Original languageEnglish
    Pages (from-to)888-893
    Number of pages6
    JournalCytokine
    Volume11
    Issue number11
    DOIs
    Publication statusPublished - Jan 1 1999

    Fingerprint

    Enterocolitis
    Interleukin-15
    Methicillin
    Methicillin-Resistant Staphylococcus aureus
    Intensive care units
    Clostridium
    Serum
    Cholangitis
    Intensive Care Units
    Diarrhea
    Pneumonia
    Infection

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Biochemistry
    • Hematology
    • Molecular Biology

    Cite this

    Mayumi, T., Takezawa, J., Takahashi, H., Yamaguchi, H., Nishimura, H., Enomoto, A., ... Yoshikai, Y. (1999). IL-15 is elevated in the patients of postoperative enterocolitis. Cytokine, 11(11), 888-893. https://doi.org/10.1006/cyto.1999.0494

    IL-15 is elevated in the patients of postoperative enterocolitis. / Mayumi, Toshihiko; Takezawa, Jun; Takahashi, Hideo; Yamaguchi, Haruo; Nishimura, Hitoshi; Enomoto, Atsushi; Ichiyama, Satoshi; Yoshikai, Yasunobu.

    In: Cytokine, Vol. 11, No. 11, 01.01.1999, p. 888-893.

    Research output: Contribution to journalArticle

    Mayumi, T, Takezawa, J, Takahashi, H, Yamaguchi, H, Nishimura, H, Enomoto, A, Ichiyama, S & Yoshikai, Y 1999, 'IL-15 is elevated in the patients of postoperative enterocolitis', Cytokine, vol. 11, no. 11, pp. 888-893. https://doi.org/10.1006/cyto.1999.0494
    Mayumi T, Takezawa J, Takahashi H, Yamaguchi H, Nishimura H, Enomoto A et al. IL-15 is elevated in the patients of postoperative enterocolitis. Cytokine. 1999 Jan 1;11(11):888-893. https://doi.org/10.1006/cyto.1999.0494
    Mayumi, Toshihiko ; Takezawa, Jun ; Takahashi, Hideo ; Yamaguchi, Haruo ; Nishimura, Hitoshi ; Enomoto, Atsushi ; Ichiyama, Satoshi ; Yoshikai, Yasunobu. / IL-15 is elevated in the patients of postoperative enterocolitis. In: Cytokine. 1999 ; Vol. 11, No. 11. pp. 888-893.
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