IL-15 is elevated in the patients of postoperative enterocolitis

Toshihiko Mayumi, Jun Takezawa, Hideo Takahashi, Haruo Yamaguchi, Hitoshi Nishimura, Atsushi Enomoto, Satoshi Ichiyama, Yasunobu Yoshikai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Serum interleukin 15 (IL-15) levels were measured in 77 patients who were consecutively admitted to our intensive care unit. Postoperative enterocolitis occurred in four patients and Methicillin-resistant Staphylococcus aureus (MRSA), but not Clostridium defficile, was identified in the faecal specimens from these patients. The IL-15 levels in the patients with MRSA enterocolitis were significantly elevated compared with those of other MRSA infections without enterocolitis including pneumonia (n = 6) and cholangitis (n = 1), and other MRSA non-colonized patients (n = 66) (21.2 ± 5.2 pg/ml vs 4.3 ± 0.2, 4.3 ± 0.5). Notably, an increase in serum IL-15 was observed just before clinical manifestation of severe diarrhoea. Our findings suggest that IL-15 may be associated in the pathogenesis of postoperative enterocolitis and its serum level may be a severity indicator of the disease.

Original languageEnglish
Pages (from-to)888-893
Number of pages6
JournalCytokine
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Molecular Biology
  • Hematology

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