TY - JOUR
T1 - IL-24
T2 - A new player in the pathogenesis of pro-inflammatory and allergic skin diseases
AU - Mitamura, Yasutaka
AU - Nunomura, Satoshi
AU - Furue, Masutaka
AU - Izuhara, Kenji
N1 - Funding Information:
We thank our collaborators for contributing to the present article: Prof. Simon J Conway at Indiana University; and Drs. Gaku Tsuji, Takeshi Nakahara, and Akiko Hashimoto-Hachiya at Kyushu University; and Drs. Yasuhiro Nanri, Masahiro Ogawa, Tomohito Yoshihara, and Miho Masuoka at Saga Medical School. The first author (YM) received the 2018 JSA Best Presentation Award by the Japanese Society of Allergology for the work.
Publisher Copyright:
© 2019 Japanese Society of Allergology
PY - 2020/7
Y1 - 2020/7
N2 - Interleukin (IL)-24 is a member of the IL-20 family of cytokines and is produced by various types of cells, such as CD4+ T cells, NK cells, mast cells, keratinocytes, bronchial epithelial cells, and myofibroblasts. Previous studies suggest that IL-24 plays an essential role in the pathogenesis of pro-inflammatory autoimmune disorders such as psoriasis, arthritis, and inflammatory bowel diseases. However, the role of IL-24 in the pathogenesis of allergic diseases has been elusive. It has already been reported that IL-24 is involved in the pathogenesis of allergic lung and skin diseases. Moreover, we have recently revealed for the first time the pivotal functions of IL-24 in IL-13–mediated skin barrier dysfunction in atopic dermatitis (AD), which is known to be a characteristic of AD caused by Th2 cytokines such as IL-4 or IL-13. In this review, we show recent advances in the basic characteristics of IL-24 and its novel functions in the pathogenesis of allergic skin inflammation, focusing on AD. A better understanding of the role of IL-24 in allergic diseases can lead to the development of new therapeutic options.
AB - Interleukin (IL)-24 is a member of the IL-20 family of cytokines and is produced by various types of cells, such as CD4+ T cells, NK cells, mast cells, keratinocytes, bronchial epithelial cells, and myofibroblasts. Previous studies suggest that IL-24 plays an essential role in the pathogenesis of pro-inflammatory autoimmune disorders such as psoriasis, arthritis, and inflammatory bowel diseases. However, the role of IL-24 in the pathogenesis of allergic diseases has been elusive. It has already been reported that IL-24 is involved in the pathogenesis of allergic lung and skin diseases. Moreover, we have recently revealed for the first time the pivotal functions of IL-24 in IL-13–mediated skin barrier dysfunction in atopic dermatitis (AD), which is known to be a characteristic of AD caused by Th2 cytokines such as IL-4 or IL-13. In this review, we show recent advances in the basic characteristics of IL-24 and its novel functions in the pathogenesis of allergic skin inflammation, focusing on AD. A better understanding of the role of IL-24 in allergic diseases can lead to the development of new therapeutic options.
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U2 - 10.1016/j.alit.2019.12.003
DO - 10.1016/j.alit.2019.12.003
M3 - Review article
C2 - 31980374
AN - SCOPUS:85078219578
SN - 1323-8930
VL - 69
SP - 405
EP - 411
JO - Allergology International
JF - Allergology International
IS - 3
ER -