IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation

Yoon Hee Kim, Yu Ninomiya, Shuya Yamashita, Motofumi Kumazoe, Yuhui Huang, Kanami Nakahara, Yeong Seon Won, Motoki Murata, Yoshinori Fujimura, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Strictinin has been shown to suppress interleukin (IL)-4-induced signal transducer and activator of transcription (STAT)-6 phosphorylation, which is a critical event for IgE class switching. However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor α (IL-4Rα) activation. Strictinin was bound to the cell surface and only localized in non-lipid raft fraction of the cells where IL-4Rα was also located. In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation.

Original languageEnglish
Pages (from-to)824-830
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume450
Issue number1
DOIs
Publication statusPublished - Jul 18 2014

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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