IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred

K. Yanagisawa, N. Hatta, I. Watanabe, Takahiko Horiuchi, H. Hasegawa, S. Fujita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have investigated the effects of interleukin-4 (IL-4) on the proliferation of chronic myelomonocytic leukemia (CMMoL) cells in the chronic and leukemic transformation phases in vitro. CMMoL cells formed colonies spontaneously in both phases. IL-4 suppressed the spontaneous growth in the chronic phase, but on the other hand, stimulated colony formation in the leukemic transformation phase. Anti-IL-6 antibody inhibited spontaneous colony formation in both phases. CMMoL cells in both phases produced high levels of IL-6, compared with those produced by acute myelogenous leukemia (AML) cells showing myelomonocytic differentiation and normal monocytes. IL-4 suppressed the IL-6 production by CMMoL cells in both phases. None of anti-IL-6, anti-macrophage colony-stimulating factor (M-CSF), anti-granulocyte-macrophage colony-stimulating factor (GM-CSF), anti-tumor necrosis factor-α (TNF-α) and anti-IL-1-β antibodies inhibited IL-4-stimulated colony formation. These results suggest that IL-4 directly stimulates the growth of CMMoL cells once leukemic transformation has occurred and that the therapeutic use of IL-4 for CMMoL should he viewed with caution, especially in the leukemic transformation phase.

Original languageEnglish
Pages (from-to)1056-1059
Number of pages4
JournalLeukemia
Volume9
Issue number6
Publication statusPublished - Jan 1 1995
Externally publishedYes

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Leukemia, Myelomonocytic, Chronic
Interleukin-4
Growth
Interleukin-6
Macrophage Colony-Stimulating Factor
Antibodies
Therapeutic Uses
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-1
Acute Myeloid Leukemia
Monocytes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Yanagisawa, K., Hatta, N., Watanabe, I., Horiuchi, T., Hasegawa, H., & Fujita, S. (1995). IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred. Leukemia, 9(6), 1056-1059.

IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred. / Yanagisawa, K.; Hatta, N.; Watanabe, I.; Horiuchi, Takahiko; Hasegawa, H.; Fujita, S.

In: Leukemia, Vol. 9, No. 6, 01.01.1995, p. 1056-1059.

Research output: Contribution to journalArticle

Yanagisawa, K, Hatta, N, Watanabe, I, Horiuchi, T, Hasegawa, H & Fujita, S 1995, 'IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred', Leukemia, vol. 9, no. 6, pp. 1056-1059.
Yanagisawa, K. ; Hatta, N. ; Watanabe, I. ; Horiuchi, Takahiko ; Hasegawa, H. ; Fujita, S. / IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred. In: Leukemia. 1995 ; Vol. 9, No. 6. pp. 1056-1059.
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