Imaging characteristics of cardiac dominant diffuse large B-cell lymphoma demonstrated with MDCT and PET/CT

Yasuka Kikuchi, Noriko Oyama-Manabe, Osamu Manabe, Masanao Naya, Yoichi M. Ito, Kanako C. Hatanaka, Hiroyuki Tsutsui, Satoshi Terae, Nagara Tamaki, Hiroki Shirato

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Abstract

Purpose: To investigate the specific imaging findings of multidetector row CT (MDCT) and PET/CT with18F-FDG in cardiac dominant diffuse large B-cell lymphoma (DLBCL) in comparison with other cardiac tumours. Methods: Five patients with DLBCL and 12 patients with other cardiac tumours including pericardial tumours were retrospectively reviewed. Among the patients with other cardiac tumours, seven had metastatic tumours, three had benign tumours, and two had other malignant cardiac tumours. The location of the cardiac mass, the encasement of the coronary artery surrounded by the mass, and pericardial effusion were evaluated using MDCT. The disease activity of the cardiac tumour was also evaluated by PET/CT. Results: Four of the five DLBCL patients had primarily right-sided cardiac lesions, which was seen significantly more frequently in DLBCL than in other cardiac tumours (p = 0.028). All cardiac DLBCL lesions were located around the atrioventricular groove and encased the coronary arteries. ECG-gated cardiac MDCT showed that there was no apparent stenosis of the coronary arteries. Large amounts of pericardial effusion were seen in all DLBCL patients. PET/CT revealed significantly higher FDG uptake in DLBCL than in other cardiac malignant tumours, with no overlap (p = 0.0007). Conclusion: The combination of a right-sided cardiac mass with a large pericardial effusion and no apparent stenosis of the encased coronary artery revealed by MDCT and a high maximum standard uptake value were the specific findings in cardiac dominant DLBCL.

Original languageEnglish
Pages (from-to)1337-1344
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume40
Issue number9
DOIs
Publication statusPublished - Sep 1 2013
Externally publishedYes

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Lymphoma, Large B-Cell, Diffuse
Heart Neoplasms
Pericardial Effusion
Coronary Stenosis
Coronary Vessels
Neoplasms
Positron Emission Tomography Computed Tomography
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Imaging characteristics of cardiac dominant diffuse large B-cell lymphoma demonstrated with MDCT and PET/CT. / Kikuchi, Yasuka; Oyama-Manabe, Noriko; Manabe, Osamu; Naya, Masanao; Ito, Yoichi M.; Hatanaka, Kanako C.; Tsutsui, Hiroyuki; Terae, Satoshi; Tamaki, Nagara; Shirato, Hiroki.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 40, No. 9, 01.09.2013, p. 1337-1344.

Research output: Contribution to journalArticle

Kikuchi, Y, Oyama-Manabe, N, Manabe, O, Naya, M, Ito, YM, Hatanaka, KC, Tsutsui, H, Terae, S, Tamaki, N & Shirato, H 2013, 'Imaging characteristics of cardiac dominant diffuse large B-cell lymphoma demonstrated with MDCT and PET/CT', European Journal of Nuclear Medicine and Molecular Imaging, vol. 40, no. 9, pp. 1337-1344. https://doi.org/10.1007/s00259-013-2436-5
Kikuchi, Yasuka ; Oyama-Manabe, Noriko ; Manabe, Osamu ; Naya, Masanao ; Ito, Yoichi M. ; Hatanaka, Kanako C. ; Tsutsui, Hiroyuki ; Terae, Satoshi ; Tamaki, Nagara ; Shirato, Hiroki. / Imaging characteristics of cardiac dominant diffuse large B-cell lymphoma demonstrated with MDCT and PET/CT. In: European Journal of Nuclear Medicine and Molecular Imaging. 2013 ; Vol. 40, No. 9. pp. 1337-1344.
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AU - Oyama-Manabe, Noriko

AU - Manabe, Osamu

AU - Naya, Masanao

AU - Ito, Yoichi M.

AU - Hatanaka, Kanako C.

AU - Tsutsui, Hiroyuki

AU - Terae, Satoshi

AU - Tamaki, Nagara

AU - Shirato, Hiroki

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N2 - Purpose: To investigate the specific imaging findings of multidetector row CT (MDCT) and PET/CT with18F-FDG in cardiac dominant diffuse large B-cell lymphoma (DLBCL) in comparison with other cardiac tumours. Methods: Five patients with DLBCL and 12 patients with other cardiac tumours including pericardial tumours were retrospectively reviewed. Among the patients with other cardiac tumours, seven had metastatic tumours, three had benign tumours, and two had other malignant cardiac tumours. The location of the cardiac mass, the encasement of the coronary artery surrounded by the mass, and pericardial effusion were evaluated using MDCT. The disease activity of the cardiac tumour was also evaluated by PET/CT. Results: Four of the five DLBCL patients had primarily right-sided cardiac lesions, which was seen significantly more frequently in DLBCL than in other cardiac tumours (p = 0.028). All cardiac DLBCL lesions were located around the atrioventricular groove and encased the coronary arteries. ECG-gated cardiac MDCT showed that there was no apparent stenosis of the coronary arteries. Large amounts of pericardial effusion were seen in all DLBCL patients. PET/CT revealed significantly higher FDG uptake in DLBCL than in other cardiac malignant tumours, with no overlap (p = 0.0007). Conclusion: The combination of a right-sided cardiac mass with a large pericardial effusion and no apparent stenosis of the encased coronary artery revealed by MDCT and a high maximum standard uptake value were the specific findings in cardiac dominant DLBCL.

AB - Purpose: To investigate the specific imaging findings of multidetector row CT (MDCT) and PET/CT with18F-FDG in cardiac dominant diffuse large B-cell lymphoma (DLBCL) in comparison with other cardiac tumours. Methods: Five patients with DLBCL and 12 patients with other cardiac tumours including pericardial tumours were retrospectively reviewed. Among the patients with other cardiac tumours, seven had metastatic tumours, three had benign tumours, and two had other malignant cardiac tumours. The location of the cardiac mass, the encasement of the coronary artery surrounded by the mass, and pericardial effusion were evaluated using MDCT. The disease activity of the cardiac tumour was also evaluated by PET/CT. Results: Four of the five DLBCL patients had primarily right-sided cardiac lesions, which was seen significantly more frequently in DLBCL than in other cardiac tumours (p = 0.028). All cardiac DLBCL lesions were located around the atrioventricular groove and encased the coronary arteries. ECG-gated cardiac MDCT showed that there was no apparent stenosis of the coronary arteries. Large amounts of pericardial effusion were seen in all DLBCL patients. PET/CT revealed significantly higher FDG uptake in DLBCL than in other cardiac malignant tumours, with no overlap (p = 0.0007). Conclusion: The combination of a right-sided cardiac mass with a large pericardial effusion and no apparent stenosis of the encased coronary artery revealed by MDCT and a high maximum standard uptake value were the specific findings in cardiac dominant DLBCL.

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