Imaging in vivo redox status in high spatial resolution with OMRI

Kazuhiro Ichikawa, Keiji Yasukawa

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)

    Abstract

    Redox-reactions are playing a significant role in regulation of homeostasis of organism. Disorder of the redox-status is related with the onset and/or propagation of oxidative diseases such as lifestyle-related diseases, including cancers and cardiac diseases, etc. In vivo imaging of redox-status is thereby important in the analysis of mechanisms of oxidative diseases and developments of new medicines for the diseases. Aminoxyl radicals are redox-sensitive reporter molecules, which lose their paramagnetic moiety by reactions of free radicals or reducing compounds. Electron spin resonance (ESR) technique has been used to measure the molecules in vivo. In vivo spatial resolution in ESR imaging is in the range of a few millimeters and is not sufficient for the detailed diagnosis of disease models. Overhauser enhanced MRI (OMRI) is an emerging free radical imaging technique, which utilised electronproton coupling to image the distribution of free radicals. In vivo imaging of redox-status is applicable with OMRI/aminoxyl radical technique. The detailed imaging analysis was demonstrated in oxidative diseases, such as tumour-bearing, neurodegeneration or gastric ulcer models. The OMRI/aminoxyl radical technique has a large potential as a diagnostic system for biomedical applications in the future.

    Original languageEnglish
    Pages (from-to)1004-1010
    Number of pages7
    JournalFree Radical Research
    Volume46
    Issue number8
    DOIs
    Publication statusPublished - Aug 1 2012

    All Science Journal Classification (ASJC) codes

    • Biochemistry

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