Imaging mass spectrometry of intravenously injected gold nanorods in mice

Masanori Fujii, Naotoshi Nakashima, Takuro Niidome, Yasuro Niidome

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Laser-induced desorption and ionization (LDI) of gold ions (Aun +: n = 13) were observed from gold nanorods in a liver tissue section (thickness: 10 -m). Larger amounts of gold nanorods produced stronger mass signals. Organic molecules in the tissue were not detected and did not inhibit the LDI processes of the gold nanorods in the tissue. Because of the selective LDI processes of the gold nanorods, the distribution of gold in the liver was successfully determined by imaging mass spectrometry.

    Original languageEnglish
    Pages (from-to)131-133
    Number of pages3
    JournalChemistry Letters
    Volume43
    Issue number1
    DOIs
    Publication statusPublished - 2014

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)

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