Imaging redox status using magnetic resonance techniques

Fuminori Hyodo, Shinji Ito, Hideo Utsumi

    Research output: Contribution to journalArticle

    Abstract

    There are many redox reactions to maintain the normal physiological conditions in the living body. A breakdown of the redox balance such as an overproduction of reactive oxygen/ nitrogen species and a decrease antioxidant defense may lead to oxidative stress. It can also induce many pathological conditions such as neurological disorders, inflammation, cancer, and ageing. Imaging of the tissue redox status could have one of the markers for drug discovery and clinical applications for novel diagnosis. Nitroxyl radicals have been utilized as a redox sensitive contrast agent in magnetic resonance imaging (MRI) and dynamic nuclear polarization (DNP)-MRI. Recently, we developed home-made DNP-MRI using the circularly transporting system of a sample for high-sensitive and redox analysis based on the anatomical structure by MRI. In this report, we demonstrate the application of the nitroxyl radical to magnetic resonance technique for monitoring the tissue redox status non-invasively.

    Original languageEnglish
    Pages (from-to)467-476
    Number of pages10
    Journalbunseki kagaku
    Volume63
    Issue number6
    DOIs
    Publication statusPublished - Jan 1 2014

    Fingerprint

    Magnetic resonance
    Imaging techniques
    Polarization
    Tissue
    Oxidative stress
    Redox reactions
    Contrast Media
    Nitrogen
    Antioxidants
    Aging of materials
    Oxidation-Reduction
    Oxygen
    Monitoring
    nitroxyl

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry

    Cite this

    Imaging redox status using magnetic resonance techniques. / Hyodo, Fuminori; Ito, Shinji; Utsumi, Hideo.

    In: bunseki kagaku, Vol. 63, No. 6, 01.01.2014, p. 467-476.

    Research output: Contribution to journalArticle

    Hyodo, Fuminori ; Ito, Shinji ; Utsumi, Hideo. / Imaging redox status using magnetic resonance techniques. In: bunseki kagaku. 2014 ; Vol. 63, No. 6. pp. 467-476.
    @article{ea6326b104b44e6298bfc0f54b7e70f5,
    title = "Imaging redox status using magnetic resonance techniques",
    abstract = "There are many redox reactions to maintain the normal physiological conditions in the living body. A breakdown of the redox balance such as an overproduction of reactive oxygen/ nitrogen species and a decrease antioxidant defense may lead to oxidative stress. It can also induce many pathological conditions such as neurological disorders, inflammation, cancer, and ageing. Imaging of the tissue redox status could have one of the markers for drug discovery and clinical applications for novel diagnosis. Nitroxyl radicals have been utilized as a redox sensitive contrast agent in magnetic resonance imaging (MRI) and dynamic nuclear polarization (DNP)-MRI. Recently, we developed home-made DNP-MRI using the circularly transporting system of a sample for high-sensitive and redox analysis based on the anatomical structure by MRI. In this report, we demonstrate the application of the nitroxyl radical to magnetic resonance technique for monitoring the tissue redox status non-invasively.",
    author = "Fuminori Hyodo and Shinji Ito and Hideo Utsumi",
    year = "2014",
    month = "1",
    day = "1",
    doi = "10.2116/bunsekikagaku.63.467",
    language = "English",
    volume = "63",
    pages = "467--476",
    journal = "Bunseki Kagaku",
    issn = "0525-1931",
    publisher = "公益社団法人日本分析化学会",
    number = "6",

    }

    TY - JOUR

    T1 - Imaging redox status using magnetic resonance techniques

    AU - Hyodo, Fuminori

    AU - Ito, Shinji

    AU - Utsumi, Hideo

    PY - 2014/1/1

    Y1 - 2014/1/1

    N2 - There are many redox reactions to maintain the normal physiological conditions in the living body. A breakdown of the redox balance such as an overproduction of reactive oxygen/ nitrogen species and a decrease antioxidant defense may lead to oxidative stress. It can also induce many pathological conditions such as neurological disorders, inflammation, cancer, and ageing. Imaging of the tissue redox status could have one of the markers for drug discovery and clinical applications for novel diagnosis. Nitroxyl radicals have been utilized as a redox sensitive contrast agent in magnetic resonance imaging (MRI) and dynamic nuclear polarization (DNP)-MRI. Recently, we developed home-made DNP-MRI using the circularly transporting system of a sample for high-sensitive and redox analysis based on the anatomical structure by MRI. In this report, we demonstrate the application of the nitroxyl radical to magnetic resonance technique for monitoring the tissue redox status non-invasively.

    AB - There are many redox reactions to maintain the normal physiological conditions in the living body. A breakdown of the redox balance such as an overproduction of reactive oxygen/ nitrogen species and a decrease antioxidant defense may lead to oxidative stress. It can also induce many pathological conditions such as neurological disorders, inflammation, cancer, and ageing. Imaging of the tissue redox status could have one of the markers for drug discovery and clinical applications for novel diagnosis. Nitroxyl radicals have been utilized as a redox sensitive contrast agent in magnetic resonance imaging (MRI) and dynamic nuclear polarization (DNP)-MRI. Recently, we developed home-made DNP-MRI using the circularly transporting system of a sample for high-sensitive and redox analysis based on the anatomical structure by MRI. In this report, we demonstrate the application of the nitroxyl radical to magnetic resonance technique for monitoring the tissue redox status non-invasively.

    UR - http://www.scopus.com/inward/record.url?scp=84940336903&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84940336903&partnerID=8YFLogxK

    U2 - 10.2116/bunsekikagaku.63.467

    DO - 10.2116/bunsekikagaku.63.467

    M3 - Article

    AN - SCOPUS:84940336903

    VL - 63

    SP - 467

    EP - 476

    JO - Bunseki Kagaku

    JF - Bunseki Kagaku

    SN - 0525-1931

    IS - 6

    ER -