Imaging Scattering Characteristics of Tissue in Transmitted Microscopy

Mihoko Shimano, Yuta Asano, Shin Ishihara, Ryoma Bise, Imari Sato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Scattering property plays a very important role in optical imaging and diagnostic applications, such as analysis of cancerous process and diagnosis of dysplasia or cancer. The existing methods focused on removing scattering components in order to visualize the spatial distribution of the reflection and absorption properties. We propose a novel method for estimating the spatial distribution of scattering property by measuring a set of intensities of the direct scattered light with each angle for each point. Our key contribution is to decompose the captured light into the direct scattered light with each angle by using varying spatial frequency of illumination patterns that can control the range of the scattered angle. By applying the method to observe a spatially inhomogeneous translucent object, we can extract the map of the angular distribution of scattering. To the best of our knowledge, this is the first method to enable visualizing a spatial map of scattering property using a conventional transmitted microscope setup. Experimental results on synthetic data and real complex materials demonstrate the effectiveness of our method for the estimation of scattering distribution.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2020 - 23rd International Conference, Proceedings
EditorsAnne L. Martel, Purang Abolmaesumi, Danail Stoyanov, Diana Mateus, Maria A. Zuluaga, S. Kevin Zhou, Daniel Racoceanu, Leo Joskowicz
PublisherSpringer Science and Business Media Deutschland GmbH
Pages236-245
Number of pages10
ISBN (Print)9783030597214
DOIs
Publication statusPublished - 2020
Event23rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2020 - Lima, Peru
Duration: Oct 4 2020Oct 8 2020

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12265 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference23rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2020
CountryPeru
CityLima
Period10/4/2010/8/20

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

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