Imatinib inhibits migration of normal human epidermal melanocytes and suppress the phosphorylation of C-kit

Jian xin Xia, Fu qiu Li, Kazunori Urabe, Jin feng Wang, Masutaka Furue

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To investigate the inhibitory effect of imatinib on the migration of normal human epidermal melanocytes (NHEM), the growth and differentiation of NHEM were measured by MTT assay. Transwell Cell Migration Assay was performed to determine the migration of NHEM following imatinib treatment. The phosphorylation of c-kit in NHEM after imatinib treatment was measured by western blot assay. Imatinib at 0.1 μM, 1.0 μM and 5.0 μM could inhibit the SCF (50 ng/mL) induced NHEM migration and suppress the phosphorylation of c-kit in NHEM. The result concluded that imatinib can inhibit SCF induced NHEM migration and suppress the c-kit phosphorylation in NHEM. This provide theoretical basis for the prevention of post-treatment recurrence of nevus spilus.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalBangladesh Journal of Pharmacology
Volume7
Issue number2
DOIs
Publication statusPublished - Jul 18 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology

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