Immnohistochemical examination on the localization of macrophages and plasma cells in induced rat periapical lesions

Akifumi Akamine, Isamu Hashiguchi, Yoshikazu Toriya, Katsumasa Maeda

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Abstract – To investigate the role of plasma cells and macro‐phages in the development of periapical lesions, we immunohistochemically examined the distribution of these inflammatory cells in experimental induced rat periapical lesions after pulpectomy. The number of EDI‐positive mononuclear cells increased rapidly, reached a plateau which remained stable between days 10 and 60, and subsequently decreased. Immunoglobulin (Ig)‐bearing plasma cells appeared alter 60 days, and, of these, IgG‐bearing plasma cells were predominant after 90 days. The radio‐graphic and histopathological findings indicated the develop‐ment of bone destruction at 10 days which continued until 60 days; tissue repair began to take place after 90 days. The results suggested that macrophages had a close relation to bone destruc‐tion and that plasma cells might participate in tissue repair rather than the development of periapical lesions.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalDental Traumatology
Issue number3
Publication statusPublished - Jan 1 1994


All Science Journal Classification (ASJC) codes

  • Oral Surgery

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