Immune response to Streptococcus pyogenes and the susceptibility to psoriasis

Masahiko Muto, Yoshihisa Fujikura, Yoshiaki Hamamoto, Makoto Ichimiya, Akiko Ohmura, Takehiko Sasazuki, Tetsuo Fukumoto, Chidori Asagami

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Monoclonal antibodies directed against type 12 Group A streptococcal cell wall antigens cross-react with nuclei and cytoplasm of cells from skin and synovium from controls, uninvolved skin of psoriatics and psoriatic plaques. Patients with psoriasis had high serum titres of antibody against the M12 (C-region) streptococcal antigen compared to controls. An abnormal immune response directed against a 'self' antigen after initiation by Group A streptococcal infection may play an important role in the exacerbation or development of psoriasis.

Original languageEnglish
Pages (from-to)S54-S55
JournalAustralasian Journal of Dermatology
Volume37
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology

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