Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8+ suppressor T cells

Hiroshi Watanabe, Sho Matsushita, Nobuhiro Kamikawaji, Kenji Hirayama, Makoto Okumura, Takehiko Sasazuki

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

The development of antiviral vaccines has been accelerated using monoclonal antibody and/or recombinant DNA techniques, the objective being to prevent grave viral infectious diseases, such as acquired immunodeficiency syndrome (AIDS), adult T-cell leukemia (ATL), and hepatitis B virus (HBV)-associated liver diseases. Certain proportions of individuals in the human population do not have any appreciable immune response to foreign antigens, either in cases of natural exposure or a planned immunization. Here we report that in the nonresponders to HB vaccine, there is an HLA-linked immune suppression gene for hepatitis B surface antigen (Is-HBsAg) controlling the nonresponsiveness to HBsAg through HBsAg-specific suppressor T cells. The Is-HBsAg is in strong linkage disequilibrium with the HLA-Bw54-DR4-DRw53 haplotype.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalHuman Immunology
Volume22
Issue number1
DOIs
Publication statusPublished - May 1988

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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