TY - JOUR
T1 - Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8+ suppressor T cells
AU - Watanabe, Hiroshi
AU - Matsushita, Sho
AU - Kamikawaji, Nobuhiro
AU - Hirayama, Kenji
AU - Okumura, Makoto
AU - Sasazuki, Takehiko
N1 - Funding Information:
We thank the staff at the Chemo-Sero-Therapy Research Institute, Kumamoto, Japan, for providing the affinity-purified HBsAg, the Kitazato Institute, Tokyo, Japan, for providing the FIB vaccine, and M. Ohara for helpful comments. This work was supported in part by a grant 60480177 (1985,1986) from the Ministry of Education, Culture, and Science, Japan.
PY - 1988/5
Y1 - 1988/5
N2 - The development of antiviral vaccines has been accelerated using monoclonal antibody and/or recombinant DNA techniques, the objective being to prevent grave viral infectious diseases, such as acquired immunodeficiency syndrome (AIDS), adult T-cell leukemia (ATL), and hepatitis B virus (HBV)-associated liver diseases. Certain proportions of individuals in the human population do not have any appreciable immune response to foreign antigens, either in cases of natural exposure or a planned immunization. Here we report that in the nonresponders to HB vaccine, there is an HLA-linked immune suppression gene for hepatitis B surface antigen (Is-HBsAg) controlling the nonresponsiveness to HBsAg through HBsAg-specific suppressor T cells. The Is-HBsAg is in strong linkage disequilibrium with the HLA-Bw54-DR4-DRw53 haplotype.
AB - The development of antiviral vaccines has been accelerated using monoclonal antibody and/or recombinant DNA techniques, the objective being to prevent grave viral infectious diseases, such as acquired immunodeficiency syndrome (AIDS), adult T-cell leukemia (ATL), and hepatitis B virus (HBV)-associated liver diseases. Certain proportions of individuals in the human population do not have any appreciable immune response to foreign antigens, either in cases of natural exposure or a planned immunization. Here we report that in the nonresponders to HB vaccine, there is an HLA-linked immune suppression gene for hepatitis B surface antigen (Is-HBsAg) controlling the nonresponsiveness to HBsAg through HBsAg-specific suppressor T cells. The Is-HBsAg is in strong linkage disequilibrium with the HLA-Bw54-DR4-DRw53 haplotype.
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U2 - 10.1016/0198-8859(88)90047-X
DO - 10.1016/0198-8859(88)90047-X
M3 - Article
C2 - 2968966
AN - SCOPUS:0023908785
VL - 22
SP - 9
EP - 17
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 1
ER -
