Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8+ suppressor T cells

Hiroshi Watanabe; Sho Matsushita; Nobuhiro Kamikawaji; Kenji Hirayama; Makoto Okumura; Takehiko Sasazuki

doi:10.1016/0198-8859(88)90047-X

Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8⁺ suppressor T cells

Hiroshi Watanabe, Sho Matsushita, Nobuhiro Kamikawaji, Kenji Hirayama, Makoto Okumura, Takehiko Sasazuki

Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

The development of antiviral vaccines has been accelerated using monoclonal antibody and/or recombinant DNA techniques, the objective being to prevent grave viral infectious diseases, such as acquired immunodeficiency syndrome (AIDS), adult T-cell leukemia (ATL), and hepatitis B virus (HBV)-associated liver diseases. Certain proportions of individuals in the human population do not have any appreciable immune response to foreign antigens, either in cases of natural exposure or a planned immunization. Here we report that in the nonresponders to HB vaccine, there is an HLA-linked immune suppression gene for hepatitis B surface antigen (Is-HBsAg) controlling the nonresponsiveness to HBsAg through HBsAg-specific suppressor T cells. The Is-HBsAg is in strong linkage disequilibrium with the HLA-Bw54-DR4-DRw53 haplotype.

Original language	English
Pages (from-to)	9-17
Number of pages	9
Journal	Human Immunology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/0198-8859(88)90047-X
Publication status	Published - May 1988

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/0198-8859(88)90047-X

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Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8⁺ suppressor T cells. / Watanabe, Hiroshi; Matsushita, Sho; Kamikawaji, Nobuhiro; Hirayama, Kenji; Okumura, Makoto; Sasazuki, Takehiko.

In: Human Immunology, Vol. 22, No. 1, 05.1988, p. 9-17.

Research output: Contribution to journal › Article › peer-review

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