Abstract
Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides(LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or β-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.
| Original language | English |
|---|---|
| Title of host publication | Invertebrate Immunity |
| Editors | Kenneth Soderhall |
| Pages | 122-136 |
| Number of pages | 15 |
| DOIs | |
| Publication status | Published - Dec 1 2010 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 708 |
| ISSN (Print) | 0065-2598 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Immunocompetent molecules and their response network in horseshoe crabs. / Kawabata, Shun-Ichiro.
Invertebrate Immunity. ed. / Kenneth Soderhall. 2010. p. 122-136 (Advances in Experimental Medicine and Biology; Vol. 708).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Immunocompetent molecules and their response network in horseshoe crabs
AU - Kawabata, Shun-Ichiro
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides(LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or β-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.
AB - Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides(LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or β-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.
UR - http://www.scopus.com/inward/record.url?scp=79960734255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960734255&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-8059-5-7
DO - 10.1007/978-1-4419-8059-5-7
M3 - Chapter
C2 - 21528696
AN - SCOPUS:79960734255
SN - 9781441980588
T3 - Advances in Experimental Medicine and Biology
SP - 122
EP - 136
BT - Invertebrate Immunity
A2 - Soderhall, Kenneth
ER -