Immunocompetent molecules and their response network in horseshoe crabs

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Citations (Scopus)

Abstract

Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides(LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or β-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.

Original languageEnglish
Title of host publicationInvertebrate Immunity
EditorsKenneth Soderhall
Pages122-136
Number of pages15
DOIs
Publication statusPublished - Dec 1 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume708
ISSN (Print)0065-2598

Fingerprint

Horseshoe Crabs
Lipopolysaccharides
Hemocytes
Molecules
Transglutaminases
Pathogens
Chemical activation
Complement C3-C5 Convertases
Peptides
Enzyme Precursors
Complement Activation
Exocytosis
Thromboplastin
Serine Proteases
Coagulation
Lectins
Innate Immunity
Epidermis
Wound Healing
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kawabata, S-I. (2010). Immunocompetent molecules and their response network in horseshoe crabs. In K. Soderhall (Ed.), Invertebrate Immunity (pp. 122-136). (Advances in Experimental Medicine and Biology; Vol. 708). https://doi.org/10.1007/978-1-4419-8059-5-7

Immunocompetent molecules and their response network in horseshoe crabs. / Kawabata, Shun-Ichiro.

Invertebrate Immunity. ed. / Kenneth Soderhall. 2010. p. 122-136 (Advances in Experimental Medicine and Biology; Vol. 708).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kawabata, S-I 2010, Immunocompetent molecules and their response network in horseshoe crabs. in K Soderhall (ed.), Invertebrate Immunity. Advances in Experimental Medicine and Biology, vol. 708, pp. 122-136. https://doi.org/10.1007/978-1-4419-8059-5-7
Kawabata S-I. Immunocompetent molecules and their response network in horseshoe crabs. In Soderhall K, editor, Invertebrate Immunity. 2010. p. 122-136. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-8059-5-7
Kawabata, Shun-Ichiro. / Immunocompetent molecules and their response network in horseshoe crabs. Invertebrate Immunity. editor / Kenneth Soderhall. 2010. pp. 122-136 (Advances in Experimental Medicine and Biology).
@inbook{1c04f11fe87a4ac5a7a973774c6ef33d,
title = "Immunocompetent molecules and their response network in horseshoe crabs",
abstract = "Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides(LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or β-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.",
author = "Shun-Ichiro Kawabata",
year = "2010",
month = "12",
day = "1",
doi = "10.1007/978-1-4419-8059-5-7",
language = "English",
isbn = "9781441980588",
series = "Advances in Experimental Medicine and Biology",
pages = "122--136",
editor = "Kenneth Soderhall",
booktitle = "Invertebrate Immunity",

}

TY - CHAP

T1 - Immunocompetent molecules and their response network in horseshoe crabs

AU - Kawabata, Shun-Ichiro

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides(LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or β-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.

AB - Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides(LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or β-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.

UR - http://www.scopus.com/inward/record.url?scp=79960734255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960734255&partnerID=8YFLogxK

U2 - 10.1007/978-1-4419-8059-5-7

DO - 10.1007/978-1-4419-8059-5-7

M3 - Chapter

C2 - 21528696

AN - SCOPUS:79960734255

SN - 9781441980588

T3 - Advances in Experimental Medicine and Biology

SP - 122

EP - 136

BT - Invertebrate Immunity

A2 - Soderhall, Kenneth

ER -