Immunogenetic analysis of patients with post-schistosomal liver cirrhosis in man

N. Ohta, Y. K. Nishimura, M. Iuchi, T. Sasazuki

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26 Citations (Scopus)

Abstract

Immune responsiveness of 121 patients with post-schistosomal liver cirrhosis to schistosomal antigens was investigated. Out of 78 patients, only five (6.4%) showed low responsiveness to schistosomal adult worm antigen whereas 73 (93.6%) were high responders. Out of 57 healthy individuals with previous schistosomal infection, low responders were found in 17.5%. The frequency of low responders to schistosomal adult worm antigen was significantly decreased in the patients with post-schistosomal liver cirrhosis (P <0.05). Out of 121 patients, a significant increase in frequency of HLA-Bw44-DEn haplotype was observed (corrected P<0.02). On the other hand, HLA-Bw52-Dw12 haplotype which was reported to be in strong linkage disequilibrium with an immune suppression gene for schistosomal adult worm antigen was significantly decreased (correct P<0.005). These observations suggested that an HLA-linked immune suppression gene controlled susceptibility or resistance to post-schistosomal liver cirrhosis through regulation of immune responsiveness of the hosts to schistosomal antigen in man.

Original languageEnglish
Pages (from-to)493-499
Number of pages7
JournalClinical and Experimental Immunology
Volume49
Issue number3
Publication statusPublished - Jan 1 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Ohta, N., Nishimura, Y. K., Iuchi, M., & Sasazuki, T. (1982). Immunogenetic analysis of patients with post-schistosomal liver cirrhosis in man. Clinical and Experimental Immunology, 49(3), 493-499.