Abstract
Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.
| Original language | English |
|---|---|
| Pages (from-to) | 1303-1308 |
| Number of pages | 6 |
| Journal | American Journal of Pathology |
| Volume | 139 |
| Issue number | 6 |
| Publication status | Published - Dec 1 1991 |
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine