Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis

T. Iwaki; J. Tateishi

Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis

T. Iwaki, J. Tateishi

Pathobiology

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.

Original language	English
Pages (from-to)	1303-1308
Number of pages	6
Journal	American Journal of Pathology
Volume	139
Issue number	6
Publication status	Published - Dec 1 1991

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine

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title = "Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis",

abstract = "Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.",

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N2 - Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.

AB - Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.

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