Abstract
Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.
| Original language | English |
|---|---|
| Pages (from-to) | 1303-1308 |
| Number of pages | 6 |
| Journal | American Journal of Pathology |
| Volume | 139 |
| Issue number | 6 |
| Publication status | Published - Dec 1 1991 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
Cite this
Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis. / Iwaki, T.; Tateishi, J.
In: American Journal of Pathology, Vol. 139, No. 6, 01.12.1991, p. 1303-1308.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis
AU - Iwaki, T.
AU - Tateishi, J.
PY - 1991/12/1
Y1 - 1991/12/1
N2 - Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.
AB - Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.
UR - http://www.scopus.com/inward/record.url?scp=0026348465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026348465&partnerID=8YFLogxK
M3 - Article
C2 - 1721490
AN - SCOPUS:0026348465
VL - 139
SP - 1303
EP - 1308
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 6
ER -