Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of αB-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of αB-crystallin in the hamartomas in conjunction with the αB- crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of αB-crystallin gene expression.
|Number of pages||6|
|Journal||American Journal of Pathology|
|Publication status||Published - Dec 1 1991|
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine