Abstract
Immunohistochemical staining for albumin (69 kDa) and fibrinogen (340 kDa), as markers of blood-retinal barrier (BRB) breakdown of the retinas of streptozotocin-treated diabetic rats, was performed. The number of rats with BRB breakdown was three of nine at 6 months, four of seven at 12 months, and three of three at 18 months. Extravasation of albumin from the retinal vessels was detected in the retinas of rats maintained for 6, 12, and 18 months, while extravasation of fibrinogen was detected only in the retinas of rats maintained for 18 months. These findings suggested that the duration of diabetes has an influence on BRB breakdown and that each substance in the blood starts to permeate the vascular wall individually.
| Original language | English |
|---|---|
| Pages (from-to) | 175-177 |
| Number of pages | 3 |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
| Volume | 231 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 1993 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Immunohistochemical detection of blood-retinal barrier breakdown in streptozotocin-diabetic rat. / Murata, Toshinori; Ishibashi, Tatsuro; Inomata, Hajime.
In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 231, No. 3, 01.03.1993, p. 175-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical detection of blood-retinal barrier breakdown in streptozotocin-diabetic rat
AU - Murata, Toshinori
AU - Ishibashi, Tatsuro
AU - Inomata, Hajime
PY - 1993/3/1
Y1 - 1993/3/1
N2 - Immunohistochemical staining for albumin (69 kDa) and fibrinogen (340 kDa), as markers of blood-retinal barrier (BRB) breakdown of the retinas of streptozotocin-treated diabetic rats, was performed. The number of rats with BRB breakdown was three of nine at 6 months, four of seven at 12 months, and three of three at 18 months. Extravasation of albumin from the retinal vessels was detected in the retinas of rats maintained for 6, 12, and 18 months, while extravasation of fibrinogen was detected only in the retinas of rats maintained for 18 months. These findings suggested that the duration of diabetes has an influence on BRB breakdown and that each substance in the blood starts to permeate the vascular wall individually.
AB - Immunohistochemical staining for albumin (69 kDa) and fibrinogen (340 kDa), as markers of blood-retinal barrier (BRB) breakdown of the retinas of streptozotocin-treated diabetic rats, was performed. The number of rats with BRB breakdown was three of nine at 6 months, four of seven at 12 months, and three of three at 18 months. Extravasation of albumin from the retinal vessels was detected in the retinas of rats maintained for 6, 12, and 18 months, while extravasation of fibrinogen was detected only in the retinas of rats maintained for 18 months. These findings suggested that the duration of diabetes has an influence on BRB breakdown and that each substance in the blood starts to permeate the vascular wall individually.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027477406&partnerID=8YFLogxK
U2 - 10.1007/BF00920943
DO - 10.1007/BF00920943
M3 - Article
C2 - 8462892
AN - SCOPUS:0027477406
VL - 231
SP - 175
EP - 177
JO - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
JF - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
SN - 0065-6100
IS - 3
ER -