Immunohistochemical detection of desmosomes in oral squamous cell carcinomas

Correlation with differentiation, mode of invasion, and metastatic potential

T. Harada, M. Shinohara, Seiji Nakamura, M. Shimada, M. Oka

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

An expression of desmosomal glycoprotein 1 (DG 1) was immunohistochemically examined in 77 biopsies and 21 metastatic cervical lymph nodes of oral squamous cell carcinomas (SCC). In the primary tumors the DG 1 expression was significantly reduced at the invasive site of poorly differentiated and highly invasive tumors. In cases of metastases in cervical lymph nodes, the DG 1 staining at the invasive site of the primary tumor was significantly less than that of nonmetastatic cases. The DG 1 expression in the metastatic lymph nodes was as weak as that in the primary tumor. Thus, we suggest that immunohistochemical investigation of DG 1 expression in oral SCC is valuable in predicting tumor behavior.

Original languageEnglish
Pages (from-to)346-349
Number of pages4
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume21
Issue number6
DOIs
Publication statusPublished - Jan 1 1992

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Desmoglein 1
Desmosomes
Squamous Cell Carcinoma
Lymph Nodes
Neoplasms
Staining and Labeling
Neoplasm Metastasis
Biopsy

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Surgery
  • Dentistry(all)

Cite this

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title = "Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: Correlation with differentiation, mode of invasion, and metastatic potential",
abstract = "An expression of desmosomal glycoprotein 1 (DG 1) was immunohistochemically examined in 77 biopsies and 21 metastatic cervical lymph nodes of oral squamous cell carcinomas (SCC). In the primary tumors the DG 1 expression was significantly reduced at the invasive site of poorly differentiated and highly invasive tumors. In cases of metastases in cervical lymph nodes, the DG 1 staining at the invasive site of the primary tumor was significantly less than that of nonmetastatic cases. The DG 1 expression in the metastatic lymph nodes was as weak as that in the primary tumor. Thus, we suggest that immunohistochemical investigation of DG 1 expression in oral SCC is valuable in predicting tumor behavior.",
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T2 - Correlation with differentiation, mode of invasion, and metastatic potential

AU - Harada, T.

AU - Shinohara, M.

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AU - Shimada, M.

AU - Oka, M.

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AB - An expression of desmosomal glycoprotein 1 (DG 1) was immunohistochemically examined in 77 biopsies and 21 metastatic cervical lymph nodes of oral squamous cell carcinomas (SCC). In the primary tumors the DG 1 expression was significantly reduced at the invasive site of poorly differentiated and highly invasive tumors. In cases of metastases in cervical lymph nodes, the DG 1 staining at the invasive site of the primary tumor was significantly less than that of nonmetastatic cases. The DG 1 expression in the metastatic lymph nodes was as weak as that in the primary tumor. Thus, we suggest that immunohistochemical investigation of DG 1 expression in oral SCC is valuable in predicting tumor behavior.

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