Abstract
Skin lesions of dermatophytosis are thought to be a result of a T cell-dependent inflammatory response that is mediated by various cytokines. We examined whether IFN-γ-positive cells (as expression of Th1 response) were present in the skin lesions of dermatophytosis in situ by immunohistochemical techniques. Mixtures of CD4-positive T cells and CD8-positive T cells were found to be present in the dermal infiltrates of the lesions. Considerable numbers of CD1a-positive cells were detected in the upper dermis and epidermis. A marked accumulation of CD68-positive cells was found in the upper dermis. IFN-γ-positive cells were present in the upper dermis of the lesions. The pattern of IFN-γ staining appeared to be intracellular in mononuclear lymphoid cells. The staining was considered to be highly specific because it could be completely blocked by preabsorption with recombinant IFN-γ. Our data support the hypothesis that the skin lesions of dermatophytosis may be associated with a Th1 response. Th1 response, which is characterized by IFN-γ release, is thought to be involved in the host defense against dermatophytes and to reflect cutaneous reaction in dermatophytosis.
| Original language | English |
|---|---|
| Pages (from-to) | 105-107 |
| Number of pages | 3 |
| Journal | European Journal of Dermatology |
| Volume | 11 |
| Issue number | 2 |
| Publication status | Published - Apr 5 2001 |
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All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
Immunohistochemical detection of interferon-γ-producing cells in dermatophytosis. / Koga, T.; Duan, H.; Urabe, K.; Furue, M.
In: European Journal of Dermatology, Vol. 11, No. 2, 05.04.2001, p. 105-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical detection of interferon-γ-producing cells in dermatophytosis
AU - Koga, T.
AU - Duan, H.
AU - Urabe, K.
AU - Furue, M.
PY - 2001/4/5
Y1 - 2001/4/5
N2 - Skin lesions of dermatophytosis are thought to be a result of a T cell-dependent inflammatory response that is mediated by various cytokines. We examined whether IFN-γ-positive cells (as expression of Th1 response) were present in the skin lesions of dermatophytosis in situ by immunohistochemical techniques. Mixtures of CD4-positive T cells and CD8-positive T cells were found to be present in the dermal infiltrates of the lesions. Considerable numbers of CD1a-positive cells were detected in the upper dermis and epidermis. A marked accumulation of CD68-positive cells was found in the upper dermis. IFN-γ-positive cells were present in the upper dermis of the lesions. The pattern of IFN-γ staining appeared to be intracellular in mononuclear lymphoid cells. The staining was considered to be highly specific because it could be completely blocked by preabsorption with recombinant IFN-γ. Our data support the hypothesis that the skin lesions of dermatophytosis may be associated with a Th1 response. Th1 response, which is characterized by IFN-γ release, is thought to be involved in the host defense against dermatophytes and to reflect cutaneous reaction in dermatophytosis.
AB - Skin lesions of dermatophytosis are thought to be a result of a T cell-dependent inflammatory response that is mediated by various cytokines. We examined whether IFN-γ-positive cells (as expression of Th1 response) were present in the skin lesions of dermatophytosis in situ by immunohistochemical techniques. Mixtures of CD4-positive T cells and CD8-positive T cells were found to be present in the dermal infiltrates of the lesions. Considerable numbers of CD1a-positive cells were detected in the upper dermis and epidermis. A marked accumulation of CD68-positive cells was found in the upper dermis. IFN-γ-positive cells were present in the upper dermis of the lesions. The pattern of IFN-γ staining appeared to be intracellular in mononuclear lymphoid cells. The staining was considered to be highly specific because it could be completely blocked by preabsorption with recombinant IFN-γ. Our data support the hypothesis that the skin lesions of dermatophytosis may be associated with a Th1 response. Th1 response, which is characterized by IFN-γ release, is thought to be involved in the host defense against dermatophytes and to reflect cutaneous reaction in dermatophytosis.
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M3 - Article
C2 - 11275803
AN - SCOPUS:0035081282
VL - 11
SP - 105
EP - 107
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 2
ER -