Immunohistochemical evaluation of squamous cell carcinoma antigen and s‐100 protein‐positive cells in human malignant esophageal tissues

Hiroyuki Matsuda, Masaki Mori, Shunichi Tsujitani, Shinji Ohno, Hiroyuki Kuwano, Keizo Sugimachi

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Localization and intensity of squamous cell carcinoma‐related antigen (SCC‐Ag) and infiltration of Langerhans' cells (LC) were investigated immunohistochemically, using anti‐SCC‐Ag and anti‐S‐100 protein antisera, respectively, in 36 cases of squamous cell carcinoma of the human esophagus. The SCC‐Ag was an indicator of histologic differentiation of squamous cell carcinoma but not of malignant potential. The population density of LC correlated well with the histologic stage, vessel invasion, and postoperative survival time. In patients with a marked infiltration of LC, survival time was longer than for those in whom the infiltration was slight (P < 0.05). The density of the LC can serve an indicator of defense of the host against the carcinoma. There was no correlation between SCC‐Ag and S‐100 protein‐positive cells.

Original languageEnglish
Pages (from-to)2261-2265
Number of pages5
JournalCancer
Volume65
Issue number10
DOIs
Publication statusPublished - May 15 1990

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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