Immunohistochemical examination of a resected advanced hilar cholangiocarcinoma arising in a 29-year-old male without primary sclerosing cholangitis

Taketoshi Suehiro, Takashi Matsumata, Tomohiro Iguchi, Kensaku Sanefuji, Ken Ichi Nomoto, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara

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Abstract

A 29-year-old man with advanced hilar cholangiocarcinoma was successfully treated with an extended right lobectomy. The carbohydrate antigen 19-9 (CA19-9) level was elevated to 939 IU/l, and the pathological findings revealed moderately differentiated tubular adenocarcinoma which involved almost the entire thickness of the hepatic duct and the adjacent liver tissue (T3) and which was associated with lymph node metastasis (N1). It was a stage IIB (T3N1M0) tubular adenocarcinoma according to UICC pathological staging. Immunohistochemical examination revealed that Ki-67, cyclin D1, and MMP-7 were positive, and 14-3-3σ and p27 were negative. The pathological and immunohistochemical findings indicated high malignant potential indicating poor prognosis. We administrated the postoperative adjunct gemcitabine combined with S-1 chemotherapy. The patient is alive without recurrence and doing well two years after surgery. We also review other reports of cholangiocarcinoma patients aged less than 30 years.

Original languageEnglish
Pages (from-to)144-152
Number of pages9
JournalCase Reports in Gastroenterology
Volume4
Issue number2
DOIs
Publication statusPublished - Nov 29 2010

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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