Immunohistochemical examination of the distribution of macrophages and CGRPimmunoreactive nerve fibers in induced rat periapical lesions

Y. Toriya, I. Hashiguchi, K. Maeda

Research output: Contribution to journalArticle

18 Citations (Scopus)


To clarify the role of calcitonin gene-related peptide (CGRP) in the development of periapical lesions, we examined the distribution of GGRP-immunoreactive (IR) nerve fibers and macrophages, and the behavior of bone tissues in experimentally induced rat periapical lesions by immunohistochemical and quantitative methods. Although no extensive changes were observed at 7 days after pulp exposure, CGRP-IR nerve fibers increased in number until 28 days with a decrease thereafter. These neural changes were closely correlated with the alteration in number of macrophages except on day 7 when macrophages were significantly increased in number as compared with control rats. Tissue repair began to take place and a decrease in number of osteoclasts was observed when the density of CGRP-IR nerve fibers reached a peak. These results suggested that there might be a close relationship between macrophages and CGRP-IR nerve fibers and that CGRPIR nerve fibers might participate in tissue repair in experimentally induced rat periapical lesions.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalEndodontics and Dental Traumatology
Issue number1
Publication statusPublished - Dec 1 1997


All Science Journal Classification (ASJC) codes

  • Dentistry (miscellaneous)

Cite this