Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland

K. Okamura, Tamotsu Kiyoshima, K. Shima, I. Kobayashi, K. Matsuo, H. Ishibashi, S. Komatsu, A. M.E. Rasul, H. Sakai

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Abstract

This study examined the immunohistochemical expression of carbohydrate antigens CA19-9 and CA125 and their relationship to various biological parameters in 27 mucoepidermoid carcinomas (MEC) and 18 adenoid cystic carcinomas (ACC) arising from salivary glands. The series showed higher immunopositivity for CA125 (67% for MEC; 33% for ACC) than for CA19-9 (59% for MEC; 11% for ACC). CA19-9 epitope was mainly expressed in cystic (MEC) and cribriform/tubular (ACC) components of carcinoma tissues. Solid components in MEC occasionally showed positive staining for CA19-9. CA125 was evenly expressed in both ACC and MEC tissues regardless of their different histological components. The positive expression of CA19-9 and CA125 in the carcinoma tissues did not influence the clinical course of patients with MEC and ACC. A significant relationship was only demonstrated between the immunohistochemical expression of CA125 and the low proliferative activity (LI) evaluated by Ki-67 immunohistochemistry. However, no significant relationship was found between LI and the patients' clinical course. These results suggest that the immunostaining for CA19-9 and CA125 provide no reliable data to predict the clinical course of patients with MEC and ACC of the salivary glands.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalOral Oncology
Volume38
Issue number3
DOIs
Publication statusPublished - May 7 2002

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Mucoepidermoid Carcinoma
Adenoid Cystic Carcinoma
Salivary Glands
Carcinoma
Epitopes
Immunohistochemistry
Carbohydrates
Staining and Labeling
Antigens

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

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Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. / Okamura, K.; Kiyoshima, Tamotsu; Shima, K.; Kobayashi, I.; Matsuo, K.; Ishibashi, H.; Komatsu, S.; Rasul, A. M.E.; Sakai, H.

In: Oral Oncology, Vol. 38, No. 3, 07.05.2002, p. 244-250.

Research output: Contribution to journalArticle

Okamura, K, Kiyoshima, T, Shima, K, Kobayashi, I, Matsuo, K, Ishibashi, H, Komatsu, S, Rasul, AME & Sakai, H 2002, 'Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland', Oral Oncology, vol. 38, no. 3, pp. 244-250. https://doi.org/10.1016/S1368-8375(01)00049-5
Okamura, K. ; Kiyoshima, Tamotsu ; Shima, K. ; Kobayashi, I. ; Matsuo, K. ; Ishibashi, H. ; Komatsu, S. ; Rasul, A. M.E. ; Sakai, H. / Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. In: Oral Oncology. 2002 ; Vol. 38, No. 3. pp. 244-250.
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