TY - JOUR
T1 - Immunohistochemical Expression of Carbohydrate Antigen 19–9 in Gastric Carcinoma
AU - Ikeda, Yoichi
AU - Mori, Masaki
AU - Kido, Akinori
AU - Shimono, Reishi
AU - Matsushima, Tetsuya
AU - Sugimachi, Keizo
AU - Saku, Motonori
PY - 1991/9
Y1 - 1991/9
N2 - Immunohistochemical localization for carbohydrate antigen 19–9 (CA19–9) was studied in the gastric tissues from 115 patients with advanced gastric carcinoma. We compared two groups: 57 patients who died of recurrence or metastases within 2 yr (group I) and 58 patients who survived 5 yr or more after resection (group II). The staining patterns were classified into negative, apical, and/or cytoplasmic type and stromal type. Thirty‐three cases (58%) of group I showed a stromal type, whereas only 17 cases (30%) of group II showed the same type. In undifferentiated type carcinoma, the stromal type was seen in 20 cases (65%) of group I and seven cases (23%) of group II. However, in differentiated type carcinoma, there was only a small difference in the appearance of stromal type between group I (50%) and group II (37%). The immunohistochemical localization for CA19–9 in the tumor tissues, particularly in undifferentiated carcinoma, will be useful in predicting the prognosis of the patients with advanced gastric carcinoma.
AB - Immunohistochemical localization for carbohydrate antigen 19–9 (CA19–9) was studied in the gastric tissues from 115 patients with advanced gastric carcinoma. We compared two groups: 57 patients who died of recurrence or metastases within 2 yr (group I) and 58 patients who survived 5 yr or more after resection (group II). The staining patterns were classified into negative, apical, and/or cytoplasmic type and stromal type. Thirty‐three cases (58%) of group I showed a stromal type, whereas only 17 cases (30%) of group II showed the same type. In undifferentiated type carcinoma, the stromal type was seen in 20 cases (65%) of group I and seven cases (23%) of group II. However, in differentiated type carcinoma, there was only a small difference in the appearance of stromal type between group I (50%) and group II (37%). The immunohistochemical localization for CA19–9 in the tumor tissues, particularly in undifferentiated carcinoma, will be useful in predicting the prognosis of the patients with advanced gastric carcinoma.
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U2 - 10.1111/j.1572-0241.1991.tb07247.x
DO - 10.1111/j.1572-0241.1991.tb07247.x
M3 - Article
C2 - 1882795
AN - SCOPUS:0026040074
VL - 86
SP - 1163
EP - 1166
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 9
ER -