Immunohistochemical expression of glutathione S-transferase-π can predict chemotherapy response in patients with nonsmall cell lung carcinoma

Fen Bai, Yoichi Nakanishi, Masayuki Kawasaki, Koichi Takayama, Jun Yatsunami, Xin Hai Pei, Nobuko Tsuruta, Kentaro Wakamatsu, Nobuyuki Hara

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

BACKGROUND. Resistance to chemotherapy agents is a major problem in the treatment of patients with nonsmall cell lung carcinoma (NSCLC). Recent studies have indicated that glutathione S-transferase-π (GST-π) may play an important role in the resistance of cancer cells to alkylating agents, including cisplatin compounds. METHODS. The expression of GST-π in tissues obtained by bronchoscopic biopsy from 38 NSCLC patients was investigated immunohistochemically. These patients were treated with a combination of cisplatin-based chemotherapy and were evaluated to determine the relationship between GST-π expression and chemotherapy response. RESULTS. Of the 38 patients, 25 (66%) were GST-π-positive and 13 (34%) were negative. There was no significant correlation between GST-π expression and the clinicopathologic factors examined (age, sex, performance status, histology, differentiation grade, and stage). Of the 38 patients treated with cisplatin- based chemotherapy, 12 patients responded to chemotherapy (overall response rate, 32%). For the patients with negative GST-π expression, the response rate was 89% (9 of 13 patients). In the patients with positive GST-π expression, the response rate was 12% (3 of 25 patients). This difference was statistically significant (P = 0.0012). CONCLUSIONS. The expression of GST- π in NSCLC patients was significantly related to response to cisplatin- based chemotherapy, and may be a useful predictor of chemotherapy response.

Original languageEnglish
Pages (from-to)416-421
Number of pages6
JournalCancer
Volume78
Issue number3
DOIs
Publication statusPublished - Aug 1 1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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