Immunohistochemical expression of sialyl Tn and sialyl Lewisa antigens in stromal tissue correlates with peritoneal dissemination in Stage IV human gastric cancer

Yoichi Ikeda, Masaki Mori, Tatsuro Kamakura, Motonori Saku, Keizo Sugimachi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Immunohistochemical expression of sialyl Tn antigen (TKH2 and B72.3), sialyl Lewisa antigen (CA19-9) and CEA was examined in 52 cases with Stage IV gastric cancer, the objective being to examine whether or not these tumour-associated antigens show different expression between peritoneal dissemination and liver metastasis. Stromal type for TKH2, B72.3, CA19-9 and CEA were seen in 14 (50%), 13 (46%), 18 (64%) and nine (32%) cases with peritoneal dissemination, respectively, and in four (17%), three (13%), four (17%) and four (17%) cases with liver metastasis, respectively. The stromal type correlated to peritoneal dissemination in TKH2 (P < 0.05) B72.3 (P < 0.05) and CA19-9 (P < 0.05). In other clinicopathological factors, the stromal type for TKH2, B72.3 and CA19-9 correlated to the undifferentiated type. However, even in the undifferentiated type group, the stromal type correlated to peritoneal dissemination in TKH2 (P < 0.05), B72.3 (P < 0.05) and CA19-9 (P < 0.05). Based on these results, the spread of sialyl-rich tumour-associated antigens into the surrounding stroma in the undifferentiated type of gastric cancer may be associated with peritoneal dissemination.

Original languageEnglish
Pages (from-to)168-175
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 1995

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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