Immunohistochemical study of intracranial cysts

T. Inoue, T. Matsushima, M. Fukui, Toru Iwaki, I. Takeshita, C. Kuromatsu

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Immunohistochemical characterization of 14 cases of intracranial cysts was performed. Among these 14 cases, five different types of cysts were represented; Rathke's cleft cyst (4 cases), neurenteric cyst (2 cases), colloid cyst (1 case), choroidal epithelial cyst (2 cases) and arachnoid cyst (5 cases). Immunohistochemical evaluation utilized antibodies to glial fibrillary acidic protein (GFAP), S-100 protein, prealbumin, carcinoembryonic antigen (CEA), and epithelial membrane antigen (EMA). GFAP-positive cels were detected in 1 Rathke's cleft cyst and in 1 choroidal epithelial cyst. S-100-positive cells were detected in 2 Rathke's cleft cysts, in 2 neurenteric cysts, in 1 colloid cyst, and in 2 choroidal epithelial cysts. Prealbumin-positive cells were detected only in the 2 choroidal epithelial cysts. CEA-positive cells were detected in 1 Rathke's cleft cyst and in 2 neurenteric cysts. EMA-positive cells were detected in all cases. Immunohistochemical study of prealbumin and S-100 protein is useful for correct diagnosis of choroidal epithelial cyst and study of CEA is useful for diagnosis of neurenteric cyst. The arachnoid cyst is negative for immunoreactivity to GFAP, S-100, prealbumin, and CEA; this can be helpful in distinguishing this type of cyst from single epithelial cysts, a task that is sometimes difficult with only light microscopy.

Original languageEnglish
Pages (from-to)576-581
Number of pages6
JournalNeurosurgery
Volume23
Issue number5
DOIs
Publication statusPublished - Jan 1 1988

Fingerprint

Cysts
Central Nervous System Cysts
Prealbumin
Neural Tube Defects
Carcinoembryonic Antigen
Glial Fibrillary Acidic Protein
Colloid Cysts
Arachnoid Cysts
Mucin-1
S100 Proteins
Protein S
Microscopy
Light
Antibodies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Inoue, T., Matsushima, T., Fukui, M., Iwaki, T., Takeshita, I., & Kuromatsu, C. (1988). Immunohistochemical study of intracranial cysts. Neurosurgery, 23(5), 576-581. https://doi.org/10.1227/00006123-198811000-00006

Immunohistochemical study of intracranial cysts. / Inoue, T.; Matsushima, T.; Fukui, M.; Iwaki, Toru; Takeshita, I.; Kuromatsu, C.

In: Neurosurgery, Vol. 23, No. 5, 01.01.1988, p. 576-581.

Research output: Contribution to journalArticle

Inoue, T, Matsushima, T, Fukui, M, Iwaki, T, Takeshita, I & Kuromatsu, C 1988, 'Immunohistochemical study of intracranial cysts', Neurosurgery, vol. 23, no. 5, pp. 576-581. https://doi.org/10.1227/00006123-198811000-00006
Inoue T, Matsushima T, Fukui M, Iwaki T, Takeshita I, Kuromatsu C. Immunohistochemical study of intracranial cysts. Neurosurgery. 1988 Jan 1;23(5):576-581. https://doi.org/10.1227/00006123-198811000-00006
Inoue, T. ; Matsushima, T. ; Fukui, M. ; Iwaki, Toru ; Takeshita, I. ; Kuromatsu, C. / Immunohistochemical study of intracranial cysts. In: Neurosurgery. 1988 ; Vol. 23, No. 5. pp. 576-581.
@article{7e15716154ef46d48ee0f41da0e4ce42,
title = "Immunohistochemical study of intracranial cysts",
abstract = "Immunohistochemical characterization of 14 cases of intracranial cysts was performed. Among these 14 cases, five different types of cysts were represented; Rathke's cleft cyst (4 cases), neurenteric cyst (2 cases), colloid cyst (1 case), choroidal epithelial cyst (2 cases) and arachnoid cyst (5 cases). Immunohistochemical evaluation utilized antibodies to glial fibrillary acidic protein (GFAP), S-100 protein, prealbumin, carcinoembryonic antigen (CEA), and epithelial membrane antigen (EMA). GFAP-positive cels were detected in 1 Rathke's cleft cyst and in 1 choroidal epithelial cyst. S-100-positive cells were detected in 2 Rathke's cleft cysts, in 2 neurenteric cysts, in 1 colloid cyst, and in 2 choroidal epithelial cysts. Prealbumin-positive cells were detected only in the 2 choroidal epithelial cysts. CEA-positive cells were detected in 1 Rathke's cleft cyst and in 2 neurenteric cysts. EMA-positive cells were detected in all cases. Immunohistochemical study of prealbumin and S-100 protein is useful for correct diagnosis of choroidal epithelial cyst and study of CEA is useful for diagnosis of neurenteric cyst. The arachnoid cyst is negative for immunoreactivity to GFAP, S-100, prealbumin, and CEA; this can be helpful in distinguishing this type of cyst from single epithelial cysts, a task that is sometimes difficult with only light microscopy.",
author = "T. Inoue and T. Matsushima and M. Fukui and Toru Iwaki and I. Takeshita and C. Kuromatsu",
year = "1988",
month = "1",
day = "1",
doi = "10.1227/00006123-198811000-00006",
language = "English",
volume = "23",
pages = "576--581",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Immunohistochemical study of intracranial cysts

AU - Inoue, T.

AU - Matsushima, T.

AU - Fukui, M.

AU - Iwaki, Toru

AU - Takeshita, I.

AU - Kuromatsu, C.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Immunohistochemical characterization of 14 cases of intracranial cysts was performed. Among these 14 cases, five different types of cysts were represented; Rathke's cleft cyst (4 cases), neurenteric cyst (2 cases), colloid cyst (1 case), choroidal epithelial cyst (2 cases) and arachnoid cyst (5 cases). Immunohistochemical evaluation utilized antibodies to glial fibrillary acidic protein (GFAP), S-100 protein, prealbumin, carcinoembryonic antigen (CEA), and epithelial membrane antigen (EMA). GFAP-positive cels were detected in 1 Rathke's cleft cyst and in 1 choroidal epithelial cyst. S-100-positive cells were detected in 2 Rathke's cleft cysts, in 2 neurenteric cysts, in 1 colloid cyst, and in 2 choroidal epithelial cysts. Prealbumin-positive cells were detected only in the 2 choroidal epithelial cysts. CEA-positive cells were detected in 1 Rathke's cleft cyst and in 2 neurenteric cysts. EMA-positive cells were detected in all cases. Immunohistochemical study of prealbumin and S-100 protein is useful for correct diagnosis of choroidal epithelial cyst and study of CEA is useful for diagnosis of neurenteric cyst. The arachnoid cyst is negative for immunoreactivity to GFAP, S-100, prealbumin, and CEA; this can be helpful in distinguishing this type of cyst from single epithelial cysts, a task that is sometimes difficult with only light microscopy.

AB - Immunohistochemical characterization of 14 cases of intracranial cysts was performed. Among these 14 cases, five different types of cysts were represented; Rathke's cleft cyst (4 cases), neurenteric cyst (2 cases), colloid cyst (1 case), choroidal epithelial cyst (2 cases) and arachnoid cyst (5 cases). Immunohistochemical evaluation utilized antibodies to glial fibrillary acidic protein (GFAP), S-100 protein, prealbumin, carcinoembryonic antigen (CEA), and epithelial membrane antigen (EMA). GFAP-positive cels were detected in 1 Rathke's cleft cyst and in 1 choroidal epithelial cyst. S-100-positive cells were detected in 2 Rathke's cleft cysts, in 2 neurenteric cysts, in 1 colloid cyst, and in 2 choroidal epithelial cysts. Prealbumin-positive cells were detected only in the 2 choroidal epithelial cysts. CEA-positive cells were detected in 1 Rathke's cleft cyst and in 2 neurenteric cysts. EMA-positive cells were detected in all cases. Immunohistochemical study of prealbumin and S-100 protein is useful for correct diagnosis of choroidal epithelial cyst and study of CEA is useful for diagnosis of neurenteric cyst. The arachnoid cyst is negative for immunoreactivity to GFAP, S-100, prealbumin, and CEA; this can be helpful in distinguishing this type of cyst from single epithelial cysts, a task that is sometimes difficult with only light microscopy.

UR - http://www.scopus.com/inward/record.url?scp=0023787103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023787103&partnerID=8YFLogxK

U2 - 10.1227/00006123-198811000-00006

DO - 10.1227/00006123-198811000-00006

M3 - Article

VL - 23

SP - 576

EP - 581

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 5

ER -