Immunohistochemical study of matrilin-1 in arthritic articular cartilage of the mandibular condyle

Shigeru Ohno, Kenichiro Murakami, Kotaro Tanimoto, Hiroki Sugiyama, Seicho Makihira, Takanori Shibata, Kiyoshi Yoneno, Yukio Kato, Kazuo Tanne

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Abstract

Background: The objective of this study was to investigate the expression of matrilin-1 in arthritic articular cartilage of the mandibular condyle by means of immunohistochemical methods. Methods: Condylar cartilage specimens were obtained from temporomandibular joints (TMJs) of 12 patients with arthritis (osteoarthritis and internal derangement) (mean age 51.8 years; age range 28-71 years) and four patients with TMJ ankylosis (mean age 44.0 years; age range 16-64 years), diagnosed clinically and with imaging examinations. Paraffin sections were immunostained with anti-matrilin-1 antibodies. Results: Matrilin-1 expression was detected in both patient groups with TMJ ankylosis and arthritis, and the level was remarkably higher in arthritic cartilage. The mean percentage of matrilin-1-producing cells to the total chondrocytes was significantly (P < 0.05) greater in the arthritic group (43.9 ± 19.2%) than in subjects with TMJ ankylosis (28.0 ± 8.7%). Conclusions: Articular chondrocytes in the TMJ condyle can express matrilin-1 and the expression is enhanced in arthritic cartilage, suggesting a presence of functional or adaptive remodeling in the condyle in response to degenerative changes in the TMJ structures.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume32
Issue number4
DOIs
Publication statusPublished - Jan 1 2003

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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