Immunohistological Localization of Peroxisome Proliferator-Activated Receptor α and γ in Human Sebaceous Glands

Masutake Furue, Masaki Takemura, Kiichiroet Nishio, Yuki Sato, Shoko Nagata, Nagisa Kan, Asako Suenaga, Kazuhisa Furue, Maiko Yoshida, Sawako Konishi, Gaku Tsuji

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The immunohistological localization of peroxisome proliferator-activated receptor a (PPARa) and PPAR g was examined in 28 pilosebaceous units in 10 paraffin-embedded normal human skin specimens. Rabbit polyclonal antibody against human PPARa and monoclonal antibody against human PPARg were used as specific primary antibodies. The nuclear and cytoplasmic expression of PPARa was detected in basal to differentiated sebocytes. In contrast, the expression of PPARg was confined to nuclei of suprabasal to early-differentiated sebocytes. The nuclear PPARg expression was present only occasionally in the basal sebocytes. These results suggest that PPARa and PPARg are integral parts of sebocyte differentiation in human sebaceous glands.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume107
Issue number11
Publication statusPublished - Nov 1 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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