Immunological, genetic, and microbiological study of family members manifesting early-onset periodontitis

Masatsugu Nakagawa, Hidemi Kurihara, Fusanori Nishimura, Osamu Isoshima, Hideo Arai, Koichi Sawada, Atsushi Nagai, Yoji Murayama

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

FROM THE STANDPOINT OF HOST-PARASITE INTERACTIONS, family studies help us understand the host defensive factors and the molecular mechanisms involved in the periodontal immune response. In this study, we report the immunotogical profile of host-defensive functions, human leukocyte antigen (HLA) phenotypes, and the microflora of a mother (rapidly progressive periodontitis), an older son (periodontally healthy), a younger son (localized juvenile periodontitis), and a daughter (localized juvenile periodontitis). We examined the peripheral neutrophil functions, phenotypic and functional analysis of peripheral lymphocytes, serum immunoglobulin G (IgG) antibody titers against periodontopathic bacteria, serological type of HLA class II antigens, and bacterial flora in all periodontal pockets. The results showed that Actinobacillus actinomycetemcomitans was dominant in the pockets of all subjects. The mother and two sons showed a depressed neutrophil chemotaxis to N-formyl-methionyl-leucyl-phenylalanine. All subjects except the older son exhibited low T4/T8 ratios. The mother and daughter had raised levels of IgG titers to Porphyromonas gingivalis. All subjects had HLA phenotypes of DRw52 and DQ1 in common. We found that the family members had similar disorders in certain defensive functions. This family has been a model for our understanding of the host defensive factors in the development of early-onset periodontitis.

Original languageEnglish
Pages (from-to)254-263
Number of pages10
JournalJournal of periodontology
Volume67
Issue number3
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

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Aggressive Periodontitis
Nuclear Family
HLA Antigens
Mothers
Neutrophils
Immunoglobulin G
Periodontal Pocket
N-Formylmethionine Leucyl-Phenylalanine
Aggregatibacter actinomycetemcomitans
Phenotype
Host-Parasite Interactions
Porphyromonas gingivalis
CD4-CD8 Ratio
Periodontitis
Histocompatibility Antigens Class II
Chemotaxis
Lymphocytes
Bacteria
Antibodies
Serum

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Immunological, genetic, and microbiological study of family members manifesting early-onset periodontitis. / Nakagawa, Masatsugu; Kurihara, Hidemi; Nishimura, Fusanori; Isoshima, Osamu; Arai, Hideo; Sawada, Koichi; Nagai, Atsushi; Murayama, Yoji.

In: Journal of periodontology, Vol. 67, No. 3, 01.01.1996, p. 254-263.

Research output: Contribution to journalArticle

Nakagawa, Masatsugu ; Kurihara, Hidemi ; Nishimura, Fusanori ; Isoshima, Osamu ; Arai, Hideo ; Sawada, Koichi ; Nagai, Atsushi ; Murayama, Yoji. / Immunological, genetic, and microbiological study of family members manifesting early-onset periodontitis. In: Journal of periodontology. 1996 ; Vol. 67, No. 3. pp. 254-263.
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