Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF

Takahiro Maeda, Taha Merghoyb, Robin M. Hobbs, Lin Dong, Manami Maeda, Johannes Zakrzewski, Marcel R.M. Van Den Brink, Arthur Zelent, Hirokazu Shigematsu, Koichi Akashi, Julie Teruya-Feldstein, Giorgio Cattoretti, Pier Paolo Pandolfi

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158 Citations (Scopus)

Abstract

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.

Original languageEnglish
Pages (from-to)860-866
Number of pages7
JournalScience
Volume316
Issue number5826
DOIs
Publication statusPublished - May 11 2007

All Science Journal Classification (ASJC) codes

  • General

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    Maeda, T., Merghoyb, T., Hobbs, R. M., Dong, L., Maeda, M., Zakrzewski, J., Van Den Brink, M. R. M., Zelent, A., Shigematsu, H., Akashi, K., Teruya-Feldstein, J., Cattoretti, G., & Pandolfi, P. P. (2007). Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science, 316(5826), 860-866. https://doi.org/10.1126/science.1140881