Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF

Takahiro Maeda, Taha Merghoyb, Robin M. Hobbs, Lin Dong, Manami Maeda, Johannes Zakrzewski, Marcel R.M. Van Den Brink, Arthur Zelent, Hirokazu Shigematsu, Koichi Akashi, Julie Teruya-Feldstein, Giorgio Cattoretti, Pier Paolo Pandolfi

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.

Original languageEnglish
Pages (from-to)860-866
Number of pages7
JournalScience
Volume316
Issue number5826
DOIs
Publication statusPublished - May 11 2007
Externally publishedYes

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Proto-Oncogenes
Allergy and Immunology
Notch Receptors
T-Lymphocytes
Hematopoietic Stem Cells
B-Lymphocytes
Bone Marrow
Lymphocytes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Maeda, T., Merghoyb, T., Hobbs, R. M., Dong, L., Maeda, M., Zakrzewski, J., ... Pandolfi, P. P. (2007). Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science, 316(5826), 860-866. https://doi.org/10.1126/science.1140881

Immunology : Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. / Maeda, Takahiro; Merghoyb, Taha; Hobbs, Robin M.; Dong, Lin; Maeda, Manami; Zakrzewski, Johannes; Van Den Brink, Marcel R.M.; Zelent, Arthur; Shigematsu, Hirokazu; Akashi, Koichi; Teruya-Feldstein, Julie; Cattoretti, Giorgio; Pandolfi, Pier Paolo.

In: Science, Vol. 316, No. 5826, 11.05.2007, p. 860-866.

Research output: Contribution to journalArticle

Maeda, T, Merghoyb, T, Hobbs, RM, Dong, L, Maeda, M, Zakrzewski, J, Van Den Brink, MRM, Zelent, A, Shigematsu, H, Akashi, K, Teruya-Feldstein, J, Cattoretti, G & Pandolfi, PP 2007, 'Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF', Science, vol. 316, no. 5826, pp. 860-866. https://doi.org/10.1126/science.1140881
Maeda, Takahiro ; Merghoyb, Taha ; Hobbs, Robin M. ; Dong, Lin ; Maeda, Manami ; Zakrzewski, Johannes ; Van Den Brink, Marcel R.M. ; Zelent, Arthur ; Shigematsu, Hirokazu ; Akashi, Koichi ; Teruya-Feldstein, Julie ; Cattoretti, Giorgio ; Pandolfi, Pier Paolo. / Immunology : Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. In: Science. 2007 ; Vol. 316, No. 5826. pp. 860-866.
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