TY - JOUR
T1 - Immunomodulatory Properties of PDLSC and Relevance to Periodontal Regeneration
AU - Wada, Naohisa
AU - Tomokiyo, Atsushi
AU - Gronthos, Stan
AU - Bartold, P. Mark
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (Project Nos. 26670826 and 15H05023), and the National Health & Medical research Council of Australia (grant No 627143).
PY - 2015/12
Y1 - 2015/12
N2 - Periodontitis, a major chronic inflammatory disease of dental tissue, causes periodontal tissue destruction and alveolar bone resorption. When large amounts of alveolar bone are lost, it is very difficult to regenerate the bone using conventional treatments. Periodontal ligament stem cells (PDLSCs) have attracted much attention as potential cell sources for alternative periodontitis regenerative treatment because of their capacity for self-renewal and multipotency. Recently, PDLSCs were found to possess immunomodulatory properties. PDLSCs lack the expression of immune co-stimulating factors and suppress immune cell proliferation following stimulation with mitogens or in mixed allogeneic lymphocyte reactions. Because of these characteristics, the anti-inflammatory effects of PDLSCs and the establishment of allogeneic PDLSC transplantation therapies have been well studied. The aim of this review is to provide an assessment of the latest findings on the immunomodulatory properties of PDLSCs and their potential clinical application for periodontal tissue regeneration.
AB - Periodontitis, a major chronic inflammatory disease of dental tissue, causes periodontal tissue destruction and alveolar bone resorption. When large amounts of alveolar bone are lost, it is very difficult to regenerate the bone using conventional treatments. Periodontal ligament stem cells (PDLSCs) have attracted much attention as potential cell sources for alternative periodontitis regenerative treatment because of their capacity for self-renewal and multipotency. Recently, PDLSCs were found to possess immunomodulatory properties. PDLSCs lack the expression of immune co-stimulating factors and suppress immune cell proliferation following stimulation with mitogens or in mixed allogeneic lymphocyte reactions. Because of these characteristics, the anti-inflammatory effects of PDLSCs and the establishment of allogeneic PDLSC transplantation therapies have been well studied. The aim of this review is to provide an assessment of the latest findings on the immunomodulatory properties of PDLSCs and their potential clinical application for periodontal tissue regeneration.
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U2 - 10.1007/s40496-015-0062-y
DO - 10.1007/s40496-015-0062-y
M3 - Review article
AN - SCOPUS:85049782528
SN - 2196-3002
VL - 2
SP - 245
EP - 251
JO - Current Oral Health Reports
JF - Current Oral Health Reports
IS - 4
ER -