Immunosuppressant therapy successfully improved regorafenib-induced severe hepatic injury in a patient with metastatic gastrointestinal stromal tumor: A case report

Miyuki Kuwayama, Keita Uchino, Kotoe Takayoshi, Masato Komoda, Motoyuki Kohjima, Makoto Nakamuta, Seiya Momosaki, Hitoshi Kusaba, Koichi Akashi, Eishi Baba

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A 75-year-old man diagnosed with ileal gastrointestinal tumor with peritoneal dissemination was subjected to salvage treatment with regorafenib at 120 mg/day. Following the initiation of the treatment, liver dysfunction appeared on day 28, and continued to worsen despite termination of the treatment. Since no increase in the levels of serum immunoglobulins of the patient was observed, and negative results were obtained for the analysis of viral markers and autoantibodies, a diagnosis of regorafenib-induced hepatitis was suggested. In consequence, the patient received steroid pulse therapy and continuous administration of prednisolone, without sufficient improvement. Liver biopsy revealed interface hepatitis with prominent plasma cell infiltration, suggesting regorafenib-induced autoimmune hepatitis. The patient was then administered azathioprine and prednisolone, which improved the hepatic injury. The present case represents the first report of successful treatment of regorafenib-induced severe hepatic injury by the use of an immunosuppressant.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalOncology Letters
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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