Impact and prediction of lymph node involvement in patients with intrahepatic cholangiocarcinoma after curative resection

Noboru Harada, Tomoharu Yoshizumi, Yo Ichi Yamashita, Yuji Soejima, Toru Ikegami, Norifumi Harimoto, shinji itoh, Yoshihiko Maehara

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factorS. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort. In the curatively-resected group (R0), lymph node involvement was the only independent predictor of long-term OS. Multiple tumors, perihilar tumor location and serum carcinoembryonic antigen (CEA) concentration >2.2 ng/ml were independent predictors of lymph node involvement before curative resection. Conclusion: Patients with ICC with multiple tumors, perihilar tumors and serum CEA concentration >2.2 ng/ml in association with lymph node involvement may need additional preoperative chemotherapy.

Original languageEnglish
Pages (from-to)3763-3769
Number of pages7
JournalAnticancer Research
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Cholangiocarcinoma
Lymph Nodes
Survival
Carcinoembryonic Antigen
Neoplasms
Serum
Recurrence
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Impact and prediction of lymph node involvement in patients with intrahepatic cholangiocarcinoma after curative resection. / Harada, Noboru; Yoshizumi, Tomoharu; Yamashita, Yo Ichi; Soejima, Yuji; Ikegami, Toru; Harimoto, Norifumi; itoh, shinji; Maehara, Yoshihiko.

In: Anticancer Research, Vol. 37, No. 7, 01.07.2017, p. 3763-3769.

Research output: Contribution to journalArticle

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AU - Harada, Noboru

AU - Yoshizumi, Tomoharu

AU - Yamashita, Yo Ichi

AU - Soejima, Yuji

AU - Ikegami, Toru

AU - Harimoto, Norifumi

AU - itoh, shinji

AU - Maehara, Yoshihiko

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N2 - Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factorS. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort. In the curatively-resected group (R0), lymph node involvement was the only independent predictor of long-term OS. Multiple tumors, perihilar tumor location and serum carcinoembryonic antigen (CEA) concentration >2.2 ng/ml were independent predictors of lymph node involvement before curative resection. Conclusion: Patients with ICC with multiple tumors, perihilar tumors and serum CEA concentration >2.2 ng/ml in association with lymph node involvement may need additional preoperative chemotherapy.

AB - Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factorS. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort. In the curatively-resected group (R0), lymph node involvement was the only independent predictor of long-term OS. Multiple tumors, perihilar tumor location and serum carcinoembryonic antigen (CEA) concentration >2.2 ng/ml were independent predictors of lymph node involvement before curative resection. Conclusion: Patients with ICC with multiple tumors, perihilar tumors and serum CEA concentration >2.2 ng/ml in association with lymph node involvement may need additional preoperative chemotherapy.

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