Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia: A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation

S. Nishiwaki, K. Miyamura, K. Ohashi, M. Kurokawa, S. Taniguchi, T. Fukuda, K. Ikegame, S. Takahashi, T. Mori, K. Imai, H. Iida, M. Hidaka, H. Sakamaki, Y. Morishima, K. Kato, R. Suzuki, J. Tanaka

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    Abstract

    Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65%, URD: 64% and CB: 57% at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47%, URD: 39% and CB: 48% in subsequent CR, P = 0.33; RD: 15%, URD: 21% and CB: 18% in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.

    Original languageEnglish
    Pages (from-to)1594-1602
    Number of pages9
    JournalAnnals of Oncology
    Volume24
    Issue number6
    DOIs
    Publication statusPublished - Jun 1 2013

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    Philadelphia Chromosome
    Cell Transplantation
    Fetal Blood
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Japan
    Tissue Donors
    Stem Cell Transplantation
    Survival
    Cord Blood Stem Cell Transplantation
    Unrelated Donors
    Multivariate Analysis
    Recurrence
    Mortality

    All Science Journal Classification (ASJC) codes

    • Hematology
    • Oncology

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    Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia : A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation. / Nishiwaki, S.; Miyamura, K.; Ohashi, K.; Kurokawa, M.; Taniguchi, S.; Fukuda, T.; Ikegame, K.; Takahashi, S.; Mori, T.; Imai, K.; Iida, H.; Hidaka, M.; Sakamaki, H.; Morishima, Y.; Kato, K.; Suzuki, R.; Tanaka, J.

    In: Annals of Oncology, Vol. 24, No. 6, 01.06.2013, p. 1594-1602.

    Research output: Contribution to journalArticle

    Nishiwaki, S, Miyamura, K, Ohashi, K, Kurokawa, M, Taniguchi, S, Fukuda, T, Ikegame, K, Takahashi, S, Mori, T, Imai, K, Iida, H, Hidaka, M, Sakamaki, H, Morishima, Y, Kato, K, Suzuki, R & Tanaka, J 2013, 'Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia: A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation', Annals of Oncology, vol. 24, no. 6, pp. 1594-1602. https://doi.org/10.1093/annonc/mds655
    Nishiwaki, S. ; Miyamura, K. ; Ohashi, K. ; Kurokawa, M. ; Taniguchi, S. ; Fukuda, T. ; Ikegame, K. ; Takahashi, S. ; Mori, T. ; Imai, K. ; Iida, H. ; Hidaka, M. ; Sakamaki, H. ; Morishima, Y. ; Kato, K. ; Suzuki, R. ; Tanaka, J. / Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia : A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation. In: Annals of Oncology. 2013 ; Vol. 24, No. 6. pp. 1594-1602.
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    title = "Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia: A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation",
    abstract = "Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65{\%}, URD: 64{\%} and CB: 57{\%} at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47{\%}, URD: 39{\%} and CB: 48{\%} in subsequent CR, P = 0.33; RD: 15{\%}, URD: 21{\%} and CB: 18{\%} in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.",
    author = "S. Nishiwaki and K. Miyamura and K. Ohashi and M. Kurokawa and S. Taniguchi and T. Fukuda and K. Ikegame and S. Takahashi and T. Mori and K. Imai and H. Iida and M. Hidaka and H. Sakamaki and Y. Morishima and K. Kato and R. Suzuki and J. Tanaka",
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    T1 - Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia

    T2 - A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation

    AU - Nishiwaki, S.

    AU - Miyamura, K.

    AU - Ohashi, K.

    AU - Kurokawa, M.

    AU - Taniguchi, S.

    AU - Fukuda, T.

    AU - Ikegame, K.

    AU - Takahashi, S.

    AU - Mori, T.

    AU - Imai, K.

    AU - Iida, H.

    AU - Hidaka, M.

    AU - Sakamaki, H.

    AU - Morishima, Y.

    AU - Kato, K.

    AU - Suzuki, R.

    AU - Tanaka, J.

    PY - 2013/6/1

    Y1 - 2013/6/1

    N2 - Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65%, URD: 64% and CB: 57% at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47%, URD: 39% and CB: 48% in subsequent CR, P = 0.33; RD: 15%, URD: 21% and CB: 18% in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.

    AB - Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65%, URD: 64% and CB: 57% at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47%, URD: 39% and CB: 48% in subsequent CR, P = 0.33; RD: 15%, URD: 21% and CB: 18% in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.

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