TY - JOUR
T1 - Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes
T2 - Fukuoka Diabetes Registry
AU - Sumi, Akiko
AU - Iwase, Masanori
AU - Nakamura, Udai
AU - Fujii, Hiroki
AU - Ohkuma, Toshiaki
AU - Ide, Hitoshi
AU - Jodai-Kitamura, Tamaki
AU - Komorita, Yuji
AU - Yoshinari, Masahito
AU - Kitazono, Takanari
N1 - Funding Information:
The authors thank Drs Yutaka Kiyohara, Yasufumi Doi, Toshiharu Ninomiya, Yoichiro Hirakawa, Shigenobu Kanba, Dongchon Kang, Shuzo Kumagai, Shinako Kaizu, Chisa Matsumoto (Kyushu University), Michiaki Kubo (RIKEN), Nobutaka Tsutsu, Nobuhiro Sasaki (Fukuoka Red Cross Hospital), Kiyohide Nunoi, Yuichi Sato, Yuji Uchizono, Ayumi Yamauchi, Kaori Itoh, Chie Miyakawa (St. Mary's Hospital), Sakae Nohara, Hirofumi Imoto, Kazushi Amano, Chie Kitaoka (Steel Memorial Yawata Hospital), Daisuke Gotoh, Toshitaka Himeno, Masae Toyonaga (Kyushu Central Hospital), Noriyasu Shinohara, Ayako Tsutsumi (Fukuoka Higashi Medical Centre), Yasuhiro Idewaki, Masahiro Nakano, Mina Matsuo, Shoko Morimoto, Tomoko Hyodo (Hakujuji Hospital), Masae Minami (Clinic Minami Masae), Miya Wada (Wada Miya Naika Clinic), Yoshifumi Yokomizo (Yokomizo Naika Clinic), Yohei Kikuchi, Masanori Kikuchi (Kikuchi Naika Clinic), Riku Nomiyama (Suzuki Naika Clinic), Shin Nakamura (Nakamura Naika Clinic), Kenji Tashiro (Oshima Eye Hospital), Mototaka Yoshinari (Yoshinari Naika Clinic), Kojiro Ichikawa (Fukutsu Naika Clinic) and Teruo Omae (Hisayama Research Institute For Lifestyle Diseases); clinical research coordinators Chiho Ohba, (Hisayama Research Institute For Lifestyle Diseases) and Yoko Nishioka (Kyushu University); and administrative staff Tomoko Matake (Hisayama Research Institute For Lifestyle Diseases) and Junko Ishimatsu (Kyushu University). We thank Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. This work was supported, in part, by the Japan Society for the Promotion of Science KAKENHI (grant numbers 23249037 and 23659353 to MI and 16K00861 to HF) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Publisher Copyright:
© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
PY - 2018/9
Y1 - 2018/9
N2 - Aims/Introduction: A younger age at menarche is associated with obesity and type 2 diabetes in adult life. The impact of early-onset menarche on obesity and glycemic control in type 2 diabetes has not been investigated. The present study examined the relationship between age at menarche and obesity and glycemic control in type 2 diabetes. Materials and Methods: A total of 2,133 patients with type 2 diabetes aged ≥20 years were divided into groups according to age at menarche (≤11, 12, 13, 14 and ≥15 years). A retrospective cohort study examined the association of menarcheal age with adiposity and hemoglobin A1c. Results: Age at menarche was inversely associated with body mass index (BMI) and abdominal circumference (P < 0.001). Each 1-year decrease in age at menarche was associated with a 0.25-kg/m2 and 0.6-cm increase in BMI and abdominal circumference, respectively, using a multivariate-adjusted model. Odds ratios for obesity and abdominal obesity significantly increased in participants with age at menarche ≤11 years after multivariable adjustments when age at menarche of 13 years was used as the reference (odds ratio 1.95, 95% CI 1.33–2.88, odds ratio 1.95, 95% CI 1.32–2.87, respectively). Younger age at menarche was significantly associated with higher hemoglobin A1c (P < 0.001); however, the association was not statistically significant after adjusting for BMI. Conclusions: Age at menarche of ≤11 years was associated with obesity after adjusting for confounding factors, and poor glycemic control associated with high BMI in type 2 diabetes. Age at menarche should be considered during clinical assessments.
AB - Aims/Introduction: A younger age at menarche is associated with obesity and type 2 diabetes in adult life. The impact of early-onset menarche on obesity and glycemic control in type 2 diabetes has not been investigated. The present study examined the relationship between age at menarche and obesity and glycemic control in type 2 diabetes. Materials and Methods: A total of 2,133 patients with type 2 diabetes aged ≥20 years were divided into groups according to age at menarche (≤11, 12, 13, 14 and ≥15 years). A retrospective cohort study examined the association of menarcheal age with adiposity and hemoglobin A1c. Results: Age at menarche was inversely associated with body mass index (BMI) and abdominal circumference (P < 0.001). Each 1-year decrease in age at menarche was associated with a 0.25-kg/m2 and 0.6-cm increase in BMI and abdominal circumference, respectively, using a multivariate-adjusted model. Odds ratios for obesity and abdominal obesity significantly increased in participants with age at menarche ≤11 years after multivariable adjustments when age at menarche of 13 years was used as the reference (odds ratio 1.95, 95% CI 1.33–2.88, odds ratio 1.95, 95% CI 1.32–2.87, respectively). Younger age at menarche was significantly associated with higher hemoglobin A1c (P < 0.001); however, the association was not statistically significant after adjusting for BMI. Conclusions: Age at menarche of ≤11 years was associated with obesity after adjusting for confounding factors, and poor glycemic control associated with high BMI in type 2 diabetes. Age at menarche should be considered during clinical assessments.
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U2 - 10.1111/jdi.12839
DO - 10.1111/jdi.12839
M3 - Article
C2 - 29575815
AN - SCOPUS:85045234053
SN - 2040-1116
VL - 9
SP - 1216
EP - 1223
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 5
ER -
