Impact of baroreflex on venous return surface.

takafumi sakamoto, Yoshinori Murayama, Atsushi Tanaka, Kazuo Sakamoto, Tomoyuki Tobushi, Keita Saku, Kazuya Hosokawa, Ken Onitsuka, Takeo Fujino, Kenji Sunagawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although Guyton's concept of venous return (VR) revolutionized circulatory physiology, the pulmonary circulation is invisible in its original framework. Since the pulmonary circulation is critical in left heart failure, we characterized the VR as a surface described by right (P(RA)) and left atrial (P(LA)) pressures and demonstrated that the VR surface was capable of representing mechanics of pulmonary as well as systemic circulation. However how baroreflex impacts the VR surface remains unknown. In 8 dogs, we isolated the carotid sinuses and replaced both ventricles with pumps. We varied cardiac output, shifted blood distribution between the systemic and pulmonary circulation at carotid sinus pressures (CSP) of 100 or 140 mmHg. The coefficient of determination of the VR surface ranged 0.96-0.99 indicating how flat the surface is. Increasing CSP decreased maximum VR (233 ± 27 vs. 216 ± 33 ml/kg/min, p<0.05), whereas did not change the slopes of VR along P(RA) or P(LA) axes. Baroreflex parallel shifts the VR surface, thereby stressed volume, without changing its slopes.

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Carotid Sinus
Pulmonary Circulation
Baroreflex
Pressure
Atrial Pressure
Mechanics
Cardiac Output
Heart Failure
Dogs
Lung
Physiology
Blood
Pumps

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Impact of baroreflex on venous return surface. / sakamoto, takafumi; Murayama, Yoshinori; Tanaka, Atsushi; Sakamoto, Kazuo; Tobushi, Tomoyuki; Saku, Keita; Hosokawa, Kazuya; Onitsuka, Ken; Fujino, Takeo; Sunagawa, Kenji.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 01.01.2011, p. 4295-4296.

Research output: Contribution to journalArticle

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AU - Saku, Keita

AU - Hosokawa, Kazuya

AU - Onitsuka, Ken

AU - Fujino, Takeo

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