Impact of baroreflex on venous return surface

Takafumi Sakamoto, Yoshinori Murayama, Atsushi Tanaka, Kazuo Sakamoto, Tomoyuki Tobushi, Keita Saku, Kazuya Hosokawa, Ken Onitsuka, Takeo Fujino, Kenji Sunagawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Background: Although Guyton's concept of venous return (VR) revolutionized circulatory physiology, the pulmonary circulation is invisible in its original framework. Since the pulmonary circulation is critical in left heart failure, we characterized the VR as a surface described by right (P RA) and left atrial (P LA) pressures and demonstrated that the VR surface was capable of representing mechanics of pulmonary as well as systemic circulation. However how baroreflex impacts the VR surface remains unknown. Methods/Results: In 8 dogs, we isolated the carotid sinuses and replaced both ventricles with pumps. We varied cardiac output, shifted blood distribution between the systemic and pulmonary circulation at carotid sinus pressures (CSP) of 100 or 140 mmHg. The coefficient of determination of the VR surface ranged 0.96-0.99 indicating how flat the surface is. Increasing CSP decreased maximum VR (23327 vs. 21633 ml/kg/min, p0.05), whereas did not change the slopes of VR along P RA or P LA axes. Conclusions: Baroreflex parallel shifts the VR surface, thereby stressed volume, without changing its slopes.

Original languageEnglish
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages4295-4296
Number of pages2
DOIs
Publication statusPublished - Dec 26 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: Aug 30 2011Sep 3 2011

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period8/30/119/3/11

Fingerprint

Carotid Sinus
Pulmonary Circulation
Baroreflex
Pressure
Atrial Pressure
Mechanics
Cardiac Output
Heart Failure
Dogs
Lung
Physiology
Blood
Pumps

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Sakamoto, T., Murayama, Y., Tanaka, A., Sakamoto, K., Tobushi, T., Saku, K., ... Sunagawa, K. (2011). Impact of baroreflex on venous return surface. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 4295-4296). [6091066] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6091066

Impact of baroreflex on venous return surface. / Sakamoto, Takafumi; Murayama, Yoshinori; Tanaka, Atsushi; Sakamoto, Kazuo; Tobushi, Tomoyuki; Saku, Keita; Hosokawa, Kazuya; Onitsuka, Ken; Fujino, Takeo; Sunagawa, Kenji.

33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 4295-4296 6091066 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sakamoto, T, Murayama, Y, Tanaka, A, Sakamoto, K, Tobushi, T, Saku, K, Hosokawa, K, Onitsuka, K, Fujino, T & Sunagawa, K 2011, Impact of baroreflex on venous return surface. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6091066, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 4295-4296, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6091066
Sakamoto T, Murayama Y, Tanaka A, Sakamoto K, Tobushi T, Saku K et al. Impact of baroreflex on venous return surface. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 4295-4296. 6091066. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6091066
Sakamoto, Takafumi ; Murayama, Yoshinori ; Tanaka, Atsushi ; Sakamoto, Kazuo ; Tobushi, Tomoyuki ; Saku, Keita ; Hosokawa, Kazuya ; Onitsuka, Ken ; Fujino, Takeo ; Sunagawa, Kenji. / Impact of baroreflex on venous return surface. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. pp. 4295-4296 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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