Impact of body mass index on CT attenuation of adrenal adenoma

Akihiro Nishie, Yoshiki Asayama, Kosei Ishigami, yasuhiro ushijima, Daisuke Kakihara, Tomohiro Nakayama, nobuhiro fujita, Koichiro Morita, Keisuke Ishimatsu, Seiichiro Takao, Tomoyuki Hida, Masaaki Sugimoto, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Objective: To investigate whether lipid metabolism-related factors regulate unenhanced CT attenuation in adrenal adenoma (AA). Materials and Methods: Thirty-six patients with surgically proven AAs were enrolled in this study. The patients’ underlying diseases were the following: primary aldosteronism (n = 24), Cushing's syndrome (n = 8), subclinical Cushing's syndrome (n = 3) and non-functioning AA (n = 1). Unenhanced CT attenuation of AAs and liver was measured. Pathologically, clear cell ratio (CCR) constituting each AA was qualitatively assessed. Clinical data including tumor diameter, body mass index (BMI), hemoglobin A1c, triglyceride, total cholesterol, blood cortisol and plasma aldosterone levels were also obtained. Simple and multiple linear regression analyses were performed to evaluate the radiological and clinicopathological factors associated with CT attenuation of AAs for all patients and separately for 25 patients with primary aldosteronism or non-functioning AA. Results: For all patients, there was a significant correlation between CT attenuation and each of CCR, BMI and blood cortisol levels (p < 0.05). For patients with primary aldosteronism or non-functioning AA, there was also a significant correlation between CT attenuation and CCR or BMI (p < 0.05). Conclusion: In addition to pathological factors, lipid-metabolism-related factors including BMI and blood cortisol levels can affect unenhanced CT attenuation of AA.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalEuropean Journal of Radiology
Volume108
DOIs
Publication statusPublished - Nov 1 2018

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Adenoma
Body Mass Index
Hyperaldosteronism
Hydrocortisone
Cushing Syndrome
Lipid Metabolism
Aldosterone
Linear Models
Hemoglobins
Triglycerides
Cholesterol
Regression Analysis
Liver
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Impact of body mass index on CT attenuation of adrenal adenoma. / Nishie, Akihiro; Asayama, Yoshiki; Ishigami, Kosei; ushijima, yasuhiro; Kakihara, Daisuke; Nakayama, Tomohiro; fujita, nobuhiro; Morita, Koichiro; Ishimatsu, Keisuke; Takao, Seiichiro; Hida, Tomoyuki; Sugimoto, Masaaki; Honda, Hiroshi.

In: European Journal of Radiology, Vol. 108, 01.11.2018, p. 184-188.

Research output: Contribution to journalArticle

Nishie, A, Asayama, Y, Ishigami, K, ushijima, Y, Kakihara, D, Nakayama, T, fujita, N, Morita, K, Ishimatsu, K, Takao, S, Hida, T, Sugimoto, M & Honda, H 2018, 'Impact of body mass index on CT attenuation of adrenal adenoma', European Journal of Radiology, vol. 108, pp. 184-188. https://doi.org/10.1016/j.ejrad.2018.09.033
Nishie, Akihiro ; Asayama, Yoshiki ; Ishigami, Kosei ; ushijima, yasuhiro ; Kakihara, Daisuke ; Nakayama, Tomohiro ; fujita, nobuhiro ; Morita, Koichiro ; Ishimatsu, Keisuke ; Takao, Seiichiro ; Hida, Tomoyuki ; Sugimoto, Masaaki ; Honda, Hiroshi. / Impact of body mass index on CT attenuation of adrenal adenoma. In: European Journal of Radiology. 2018 ; Vol. 108. pp. 184-188.
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AU - Kakihara, Daisuke

AU - Nakayama, Tomohiro

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