Impact of Ca2+ signaling on B cell function

Yoshihiro Baba, Tomohiro Kurosaki

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

In B cells, changes in intracellular concentration of Ca2+ drive signal transduction to initiate changes in gene expression and various cellular events, including apoptosis and differentiation. B cell receptor engagement causes a transient Ca2+ flux from the endoplasmic reticulum Ca2+ store, followed by a continuous increase in intracellular Ca2+ concentration, mainly resulting from store-operated Ca2+ entry (SOCE). The recent identification of stromal interaction molecule (STIM) and Orai as essential components for SOCE has allowed researchers to probe further the role of Ca2+ signals in B cell biology. Here, we summarize the B cell signaling pathways that lead to SOCE, the role of Ca2+ signals in B cell regulatory function, and how a breakdown in the balance of Ca2+ signals is associated with immune-related disease.

Original languageEnglish
Pages (from-to)589-594
Number of pages6
JournalTrends in Immunology
Volume32
Issue number12
DOIs
Publication statusPublished - Dec 1 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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