Impact of components of denture acrylic resin on gingival cell growth and sensitivity to Candida albicans adhesion

Seicho Makihira, H. Nikawa, M. Nishimura, H. Egusa, S. Sadamori, R. P. Rahayu, H. Nishimura, T. Hamada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of four liquid components of denture acrylic resin on host cell activity and fungal adhesion were investigated in this study. The low concentration (1 μmol l1) of the liquid components caused no change in the activities and morphologies of the gingival fibroblast cells, compared with control and dimethylsulphoxide-exposed cells. However, when the cells were exposed to high concentrations (1 mmol l1) of benzoyl peroxide, morphological change was observed, implying that the exposure of the cells to high concentrations of the liquid components of denture acrylic causes the loss of adhesion proteins from the cells. Thus the amount of Candida adhesion to human gingival cells was analysed, and the adherence of fungi to the cell was significantly reduced when the cells were pre-exposed to methyl methacrylate, hydroquinone and benzoyl peroxide at a concentration of 1 μmol l1 (P < 0.01), which did not affect either the cell viability or the cell morphology. These results, taken together, suggested that the renewal of dentures could be a possible therapeutic and/or preventive aid for oral candidosis in denture-wearing patients.

Original languageEnglish
Pages (from-to)300-305
Number of pages6
JournalMycoses
Volume45
Issue number7-8
DOIs
Publication statusPublished - Nov 17 2002

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Acrylic Resins
Dentures
Candida albicans
Growth
Benzoyl Peroxide
Oral Candidiasis
Methacrylates
Dimethyl Sulfoxide
Candida
Cell Adhesion
Cell Survival
Fungi
Fibroblasts

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

Makihira, S., Nikawa, H., Nishimura, M., Egusa, H., Sadamori, S., Rahayu, R. P., ... Hamada, T. (2002). Impact of components of denture acrylic resin on gingival cell growth and sensitivity to Candida albicans adhesion. Mycoses, 45(7-8), 300-305. https://doi.org/10.1046/j.1439-0507.2002.00769.x

Impact of components of denture acrylic resin on gingival cell growth and sensitivity to Candida albicans adhesion. / Makihira, Seicho; Nikawa, H.; Nishimura, M.; Egusa, H.; Sadamori, S.; Rahayu, R. P.; Nishimura, H.; Hamada, T.

In: Mycoses, Vol. 45, No. 7-8, 17.11.2002, p. 300-305.

Research output: Contribution to journalArticle

Makihira, S, Nikawa, H, Nishimura, M, Egusa, H, Sadamori, S, Rahayu, RP, Nishimura, H & Hamada, T 2002, 'Impact of components of denture acrylic resin on gingival cell growth and sensitivity to Candida albicans adhesion', Mycoses, vol. 45, no. 7-8, pp. 300-305. https://doi.org/10.1046/j.1439-0507.2002.00769.x
Makihira, Seicho ; Nikawa, H. ; Nishimura, M. ; Egusa, H. ; Sadamori, S. ; Rahayu, R. P. ; Nishimura, H. ; Hamada, T. / Impact of components of denture acrylic resin on gingival cell growth and sensitivity to Candida albicans adhesion. In: Mycoses. 2002 ; Vol. 45, No. 7-8. pp. 300-305.
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