Impact of donor age and recipient status on left-lobe graft for living donor adult liver transplantation

Tomoharu Yoshizumi, Akinobu Taketomi, Yuji Soejima, Hideaki Uchiyama, Toru Ikegami, Noboru Harada, Hiroto Kayashima, Yo Ichi Yamashita, Mitsuo Shimada, Yoshihiko Maehara

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Abstract

Donor safety is the priority when performing a living donor adult liver transplantation (LDALT). We herein present our findings using left-lobe graft in LDALT. Data on 119 recipients who underwent the LDALT, and on 119 donors who underwent extended left lobectomy were reviewed. The recipients were divided into groups above (n = 19) and below (n = 100) 50 years of donor age, into groups above (n = 63) and below (n = 56) 40% of graft size (graft volume/standard liver volume, GV/SLV), and above (n = 25) and below (n = 94) 20 of pre-operative model for end-stage liver disease (MELD). Total bilirubin (TB), volume of ascites, prothrombin time international normalized ratio on postoperative day 14 or survival rates were compared. TB (mg/dl) or volume of ascites (ml) of the group in donor age < 50 years was better than that of the group in donor age ≥ 50 years (7.4 vs. 14.7 or 788 vs. 1379, P < 0.001 or P < 0.005, respectively). The graft and patient survival rates of the lower MELD group tended to be better than that of the higher MELD group. LDALT can be safely performed using a left-lobe graft. However, when using the graft from the donor ≥ 50 years, especially for the recipients with the MELD ≥ 20, the indications should be carefully discussed.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalTransplant International
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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Living Donors
Liver Transplantation
End Stage Liver Disease
Tissue Donors
Transplants
Bilirubin
Ascites
Survival Rate
International Normalized Ratio
Prothrombin Time
Graft Survival
Age Groups
Safety
Liver

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Impact of donor age and recipient status on left-lobe graft for living donor adult liver transplantation. / Yoshizumi, Tomoharu; Taketomi, Akinobu; Soejima, Yuji; Uchiyama, Hideaki; Ikegami, Toru; Harada, Noboru; Kayashima, Hiroto; Yamashita, Yo Ichi; Shimada, Mitsuo; Maehara, Yoshihiko.

In: Transplant International, Vol. 21, No. 1, 01.01.2008, p. 81-88.

Research output: Contribution to journalArticle

Yoshizumi, Tomoharu ; Taketomi, Akinobu ; Soejima, Yuji ; Uchiyama, Hideaki ; Ikegami, Toru ; Harada, Noboru ; Kayashima, Hiroto ; Yamashita, Yo Ichi ; Shimada, Mitsuo ; Maehara, Yoshihiko. / Impact of donor age and recipient status on left-lobe graft for living donor adult liver transplantation. In: Transplant International. 2008 ; Vol. 21, No. 1. pp. 81-88.
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