Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation

Hideya Kamei, Satohiro Masuda, Taro Nakamura, Yasuhiro Fujimoto, Fumitaka Oike, Yasuhiro Ogura, Yasutsugu Takada, Nobuyuki Hamajima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

It has previously been demonstrated that glutathione S-transferase T1 (GSTT1) genetic mismatch between recipient and donor is a risk factor for developing immune-mediated hepatitis following liver transplantation and for antibody-mediated rejection in renal transplantation. Little is known whether the GSTT1 gene polymorphism affects the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Patients underwent LDLT at Nagoya University or Kyoto University, Japan, between 2004 and 2009. Genotyping of GSTT1 genes (null or present genotype) was conducted in recipients and donors. A total of 155 LDLT cases were examined. Forty-seven recipients (30.3%) developed early ACR. There was no association of recipient GSTT1 genotype with ACR incidence. However, ACR incidence was significantly higher in recipients transplanted from GSTT1 present genotype donors than in those transplanted from GSTT1 null genotype donors [odds ratio (OR). =. 2.64, 95% confidence interval (CI). =. 1.12-5.83, p=. 0.016]. Moreover, GSTT1 recipient/donor genotype mismatch (present/null or null/present) was significantly associated with ACR development (OR. =. 2.28, 95% CI. =. 1.12-4.61, p=. 0.022). The genotyping of GSTT1 in recipients and donors might be useful to stratify the liver transplant recipients according to risk of ACR.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalTransplant Immunology
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

Fingerprint

Living Donors
Liver Transplantation
Tissue Donors
Genotype
Genes
Incidence
Odds Ratio
Confidence Intervals
glutathione S-transferase T1
Kidney Transplantation
Hepatitis
Japan
Antibodies
Liver

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Transplantation

Cite this

Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation. / Kamei, Hideya; Masuda, Satohiro; Nakamura, Taro; Fujimoto, Yasuhiro; Oike, Fumitaka; Ogura, Yasuhiro; Takada, Yasutsugu; Hamajima, Nobuyuki.

In: Transplant Immunology, Vol. 28, No. 1, 01.01.2013, p. 14-17.

Research output: Contribution to journalArticle

Kamei, Hideya ; Masuda, Satohiro ; Nakamura, Taro ; Fujimoto, Yasuhiro ; Oike, Fumitaka ; Ogura, Yasuhiro ; Takada, Yasutsugu ; Hamajima, Nobuyuki. / Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation. In: Transplant Immunology. 2013 ; Vol. 28, No. 1. pp. 14-17.
@article{60c491355cba488792b68a4e72b0d587,
title = "Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation",
abstract = "It has previously been demonstrated that glutathione S-transferase T1 (GSTT1) genetic mismatch between recipient and donor is a risk factor for developing immune-mediated hepatitis following liver transplantation and for antibody-mediated rejection in renal transplantation. Little is known whether the GSTT1 gene polymorphism affects the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Patients underwent LDLT at Nagoya University or Kyoto University, Japan, between 2004 and 2009. Genotyping of GSTT1 genes (null or present genotype) was conducted in recipients and donors. A total of 155 LDLT cases were examined. Forty-seven recipients (30.3{\%}) developed early ACR. There was no association of recipient GSTT1 genotype with ACR incidence. However, ACR incidence was significantly higher in recipients transplanted from GSTT1 present genotype donors than in those transplanted from GSTT1 null genotype donors [odds ratio (OR). =. 2.64, 95{\%} confidence interval (CI). =. 1.12-5.83, p=. 0.016]. Moreover, GSTT1 recipient/donor genotype mismatch (present/null or null/present) was significantly associated with ACR development (OR. =. 2.28, 95{\%} CI. =. 1.12-4.61, p=. 0.022). The genotyping of GSTT1 in recipients and donors might be useful to stratify the liver transplant recipients according to risk of ACR.",
author = "Hideya Kamei and Satohiro Masuda and Taro Nakamura and Yasuhiro Fujimoto and Fumitaka Oike and Yasuhiro Ogura and Yasutsugu Takada and Nobuyuki Hamajima",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.trim.2012.11.002",
language = "English",
volume = "28",
pages = "14--17",
journal = "Transplant Immunology",
issn = "0966-3274",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation

AU - Kamei, Hideya

AU - Masuda, Satohiro

AU - Nakamura, Taro

AU - Fujimoto, Yasuhiro

AU - Oike, Fumitaka

AU - Ogura, Yasuhiro

AU - Takada, Yasutsugu

AU - Hamajima, Nobuyuki

PY - 2013/1/1

Y1 - 2013/1/1

N2 - It has previously been demonstrated that glutathione S-transferase T1 (GSTT1) genetic mismatch between recipient and donor is a risk factor for developing immune-mediated hepatitis following liver transplantation and for antibody-mediated rejection in renal transplantation. Little is known whether the GSTT1 gene polymorphism affects the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Patients underwent LDLT at Nagoya University or Kyoto University, Japan, between 2004 and 2009. Genotyping of GSTT1 genes (null or present genotype) was conducted in recipients and donors. A total of 155 LDLT cases were examined. Forty-seven recipients (30.3%) developed early ACR. There was no association of recipient GSTT1 genotype with ACR incidence. However, ACR incidence was significantly higher in recipients transplanted from GSTT1 present genotype donors than in those transplanted from GSTT1 null genotype donors [odds ratio (OR). =. 2.64, 95% confidence interval (CI). =. 1.12-5.83, p=. 0.016]. Moreover, GSTT1 recipient/donor genotype mismatch (present/null or null/present) was significantly associated with ACR development (OR. =. 2.28, 95% CI. =. 1.12-4.61, p=. 0.022). The genotyping of GSTT1 in recipients and donors might be useful to stratify the liver transplant recipients according to risk of ACR.

AB - It has previously been demonstrated that glutathione S-transferase T1 (GSTT1) genetic mismatch between recipient and donor is a risk factor for developing immune-mediated hepatitis following liver transplantation and for antibody-mediated rejection in renal transplantation. Little is known whether the GSTT1 gene polymorphism affects the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Patients underwent LDLT at Nagoya University or Kyoto University, Japan, between 2004 and 2009. Genotyping of GSTT1 genes (null or present genotype) was conducted in recipients and donors. A total of 155 LDLT cases were examined. Forty-seven recipients (30.3%) developed early ACR. There was no association of recipient GSTT1 genotype with ACR incidence. However, ACR incidence was significantly higher in recipients transplanted from GSTT1 present genotype donors than in those transplanted from GSTT1 null genotype donors [odds ratio (OR). =. 2.64, 95% confidence interval (CI). =. 1.12-5.83, p=. 0.016]. Moreover, GSTT1 recipient/donor genotype mismatch (present/null or null/present) was significantly associated with ACR development (OR. =. 2.28, 95% CI. =. 1.12-4.61, p=. 0.022). The genotyping of GSTT1 in recipients and donors might be useful to stratify the liver transplant recipients according to risk of ACR.

UR - http://www.scopus.com/inward/record.url?scp=84873056405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873056405&partnerID=8YFLogxK

U2 - 10.1016/j.trim.2012.11.002

DO - 10.1016/j.trim.2012.11.002

M3 - Article

C2 - 23153768

AN - SCOPUS:84873056405

VL - 28

SP - 14

EP - 17

JO - Transplant Immunology

JF - Transplant Immunology

SN - 0966-3274

IS - 1

ER -