Impact of interstitial changes on radiation pneumonitis after stereotactic body radiation therapy for lung cancer

Tadamasa Yoshitake, Yoshiyuki Shioyama, Kaori Asai, Katsumasa Nakamura, Tomonari Sasaki, Ohga Saiji, Takeshi Kamitani, Toshihiro Yamaguchi, Kaori Ohshima, Keiji Matsumoto, Satoshi Kawanami, Hiroshi Honda

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Aim: The aim of the present study was to evaluate the impact of interstitial changes (IC) on radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for lung cancer. Patients and Methods: We analyzed 260 consecutive patients with primary lung cancer treated with SBRT. According to the presence or absence of IC on the pre-treatment computed tomography, patients were divided into two groups: an IC group (n=18) and a non-IC group (n=242). Results: RP of grade 2 or more was observed in 9 (50.0%) and 14 (6.7%) patients in the IC and non-IC group, respectively. All three patients with grade 5 RP were in the IC group. As indicated by multivariate analysis, the presence of IC was the only significant predictive factor of RP of grade 2 or more. Conclusion: The presence of IC was a significant indicator of grade 2 or more RP after SBRT for patients with lung cancer.

Original languageEnglish
Pages (from-to)4909-4914
Number of pages6
JournalAnticancer Research
Volume35
Issue number9
Publication statusPublished - Jan 1 2015

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Radiation Pneumonitis
Lung Neoplasms
Radiotherapy
Multivariate Analysis
Tomography

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Impact of interstitial changes on radiation pneumonitis after stereotactic body radiation therapy for lung cancer. / Yoshitake, Tadamasa; Shioyama, Yoshiyuki; Asai, Kaori; Nakamura, Katsumasa; Sasaki, Tomonari; Saiji, Ohga; Kamitani, Takeshi; Yamaguchi, Toshihiro; Ohshima, Kaori; Matsumoto, Keiji; Kawanami, Satoshi; Honda, Hiroshi.

In: Anticancer Research, Vol. 35, No. 9, 01.01.2015, p. 4909-4914.

Research output: Contribution to journalArticle

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author = "Tadamasa Yoshitake and Yoshiyuki Shioyama and Kaori Asai and Katsumasa Nakamura and Tomonari Sasaki and Ohga Saiji and Takeshi Kamitani and Toshihiro Yamaguchi and Kaori Ohshima and Keiji Matsumoto and Satoshi Kawanami and Hiroshi Honda",
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AU - Yoshitake, Tadamasa

AU - Shioyama, Yoshiyuki

AU - Asai, Kaori

AU - Nakamura, Katsumasa

AU - Sasaki, Tomonari

AU - Saiji, Ohga

AU - Kamitani, Takeshi

AU - Yamaguchi, Toshihiro

AU - Ohshima, Kaori

AU - Matsumoto, Keiji

AU - Kawanami, Satoshi

AU - Honda, Hiroshi

PY - 2015/1/1

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AB - Aim: The aim of the present study was to evaluate the impact of interstitial changes (IC) on radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for lung cancer. Patients and Methods: We analyzed 260 consecutive patients with primary lung cancer treated with SBRT. According to the presence or absence of IC on the pre-treatment computed tomography, patients were divided into two groups: an IC group (n=18) and a non-IC group (n=242). Results: RP of grade 2 or more was observed in 9 (50.0%) and 14 (6.7%) patients in the IC and non-IC group, respectively. All three patients with grade 5 RP were in the IC group. As indicated by multivariate analysis, the presence of IC was the only significant predictive factor of RP of grade 2 or more. Conclusion: The presence of IC was a significant indicator of grade 2 or more RP after SBRT for patients with lung cancer.

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