Impact of interstitial changes on radiation pneumonitis after stereotactic body radiation therapy for lung cancer

Tadamasa Yoshitake; Yoshiyuki Shioyama; Kaori Asai; Katsumasa Nakamura; Tomonari Sasaki; Saiji Ohga; Takeshi Kamitani; Toshihiro Yamaguchi; Kaori Ohshima; Keiji Matsumoto; Satoshi Kawanami; Hiroshi Honda

Impact of interstitial changes on radiation pneumonitis after stereotactic body radiation therapy for lung cancer

Tadamasa Yoshitake, Yoshiyuki Shioyama, Kaori Asai, Katsumasa Nakamura, Tomonari Sasaki, Saiji Ohga, Takeshi Kamitani, Toshihiro Yamaguchi, Kaori Ohshima, Keiji Matsumoto, Satoshi Kawanami, Hiroshi Honda

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Aim: The aim of the present study was to evaluate the impact of interstitial changes (IC) on radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for lung cancer. Patients and Methods: We analyzed 260 consecutive patients with primary lung cancer treated with SBRT. According to the presence or absence of IC on the pre-treatment computed tomography, patients were divided into two groups: an IC group (n=18) and a non-IC group (n=242). Results: RP of grade 2 or more was observed in 9 (50.0%) and 14 (6.7%) patients in the IC and non-IC group, respectively. All three patients with grade 5 RP were in the IC group. As indicated by multivariate analysis, the presence of IC was the only significant predictive factor of RP of grade 2 or more. Conclusion: The presence of IC was a significant indicator of grade 2 or more RP after SBRT for patients with lung cancer.

Original language	English
Pages (from-to)	4909-4914
Number of pages	6
Journal	Anticancer research
Volume	35
Issue number	9
Publication status	Published - Sept 1 2015

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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Cite this

@article{efc79cdf32e647ea8cb151dffc8565f4,

title = "Impact of interstitial changes on radiation pneumonitis after stereotactic body radiation therapy for lung cancer",

abstract = "Aim: The aim of the present study was to evaluate the impact of interstitial changes (IC) on radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for lung cancer. Patients and Methods: We analyzed 260 consecutive patients with primary lung cancer treated with SBRT. According to the presence or absence of IC on the pre-treatment computed tomography, patients were divided into two groups: an IC group (n=18) and a non-IC group (n=242). Results: RP of grade 2 or more was observed in 9 (50.0%) and 14 (6.7%) patients in the IC and non-IC group, respectively. All three patients with grade 5 RP were in the IC group. As indicated by multivariate analysis, the presence of IC was the only significant predictive factor of RP of grade 2 or more. Conclusion: The presence of IC was a significant indicator of grade 2 or more RP after SBRT for patients with lung cancer.",

author = "Tadamasa Yoshitake and Yoshiyuki Shioyama and Kaori Asai and Katsumasa Nakamura and Tomonari Sasaki and Saiji Ohga and Takeshi Kamitani and Toshihiro Yamaguchi and Kaori Ohshima and Keiji Matsumoto and Satoshi Kawanami and Hiroshi Honda",

year = "2015",

month = sep,

day = "1",

language = "English",

volume = "35",

pages = "4909--4914",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Impact of interstitial changes on radiation pneumonitis after stereotactic body radiation therapy for lung cancer

AU - Yoshitake, Tadamasa

AU - Shioyama, Yoshiyuki

AU - Asai, Kaori

AU - Nakamura, Katsumasa

AU - Sasaki, Tomonari

AU - Ohga, Saiji

AU - Kamitani, Takeshi

AU - Yamaguchi, Toshihiro

AU - Ohshima, Kaori

AU - Matsumoto, Keiji

AU - Kawanami, Satoshi

AU - Honda, Hiroshi

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Aim: The aim of the present study was to evaluate the impact of interstitial changes (IC) on radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for lung cancer. Patients and Methods: We analyzed 260 consecutive patients with primary lung cancer treated with SBRT. According to the presence or absence of IC on the pre-treatment computed tomography, patients were divided into two groups: an IC group (n=18) and a non-IC group (n=242). Results: RP of grade 2 or more was observed in 9 (50.0%) and 14 (6.7%) patients in the IC and non-IC group, respectively. All three patients with grade 5 RP were in the IC group. As indicated by multivariate analysis, the presence of IC was the only significant predictive factor of RP of grade 2 or more. Conclusion: The presence of IC was a significant indicator of grade 2 or more RP after SBRT for patients with lung cancer.

AB - Aim: The aim of the present study was to evaluate the impact of interstitial changes (IC) on radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for lung cancer. Patients and Methods: We analyzed 260 consecutive patients with primary lung cancer treated with SBRT. According to the presence or absence of IC on the pre-treatment computed tomography, patients were divided into two groups: an IC group (n=18) and a non-IC group (n=242). Results: RP of grade 2 or more was observed in 9 (50.0%) and 14 (6.7%) patients in the IC and non-IC group, respectively. All three patients with grade 5 RP were in the IC group. As indicated by multivariate analysis, the presence of IC was the only significant predictive factor of RP of grade 2 or more. Conclusion: The presence of IC was a significant indicator of grade 2 or more RP after SBRT for patients with lung cancer.

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M3 - Article

C2 - 26254387

AN - SCOPUS:84939607014

SN - 0250-7005

VL - 35

SP - 4909

EP - 4914

JO - Anticancer Research

JF - Anticancer Research

IS - 9

ER -

Impact of interstitial changes on radiation pneumonitis after stereotactic body radiation therapy for lung cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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