Impact of perioperative peripheral blood values on postoperative complications after esophageal surgery

Hiroshi Saeki, Takanobu Masuda, Satoko Okada, Koji Ando, Masahiko Sugiyama, Keiji Yoshinaga, Kazuya Endo, Noriaki Sadanaga, Yasunori Emi, Yoshihiro Kakeji, Masaru Morita, Natsumi Yamashita, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Purpose: Prediction of the postoperative course of esophagectomy is an important part of the strict perioperative management of patients undergoing surgery for esophageal cancer. Methods: To evaluate their clinical importance, peripheral blood values, including white blood cell count (WBC), lymphocyte count, and the levels of total protein, transferrin, factor XIII, D-dimer, fibrin, and fibrinogen degradation products (FDP) were measured before and after esophagectomy for esophageal cancer in 24 patients. Results: The preoperative WBC and the pre- and postoperative lymphocyte count were decreased remarkably in patients who received preoperative chemoradiotherapy. The values of perioperative serum transferrin were significantly lower in patients with postoperative pneumonia than in those without. The activity of plasma factor XIII was suppressed on postoperative day (POD) 7 in patients with pneumonia and on POD 14 in patients with leakage. Conclusions: These results suggest that patients who receive preoperative chemoradiotherapy are potentially immunosuppressed, the preoperative serum transferrin level is a possible predictive marker of postoperative pneumonia, and suppression of factor XIII activity is related to anastomotic insufficiency.

Original languageEnglish
Pages (from-to)626-631
Number of pages6
JournalSurgery today
Issue number7
Publication statusPublished - Jul 2010

All Science Journal Classification (ASJC) codes

  • Surgery


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